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amyloid-beta

The image shows the impact of the drug on BACE.

·December 6, 2013·3 min read

Alzheimer’s Drug Discovery: Looking Under the Right ROCK

Researchers have discovered a potential drug which can force BACE into different parts of a cell, reducing its ability to produce amyloid beta.

The image shows the stained neural stem cells.

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·December 6, 2013·3 min read

Human Stem Cells Predict Efficacy of Alzheimer Drugs

Researchers transform iPSCs into neurons to test the efficacy of drugs to treat Alzheimer's disease.

The image shows comparison slides from this alzheimer's study.

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·December 6, 2013·5 min read

Study Treats Alzheimer’s by Delivering Protein Across Blood-Brain Barrier

Researchers discover a way to traverse the blood-brain barrier and retinal-blood barrier to deliver a molecule which degrades the main component of Alzheimer's plaques.

The image shows the tau proteins associated with Alzheimer's disease.

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·June 19, 2013·3 min read

New Alzheimer’s Research Suggests Possible Cause: The Interaction of Proteins in the Brain

Researchers discover by looking at amyloid-beta and tau independently that the interaction between the proteins could be the key to the cognitive decline associated with Alzheimer's disease. As the interaction between the two proteins increased, the progression of Alzheimer's worsened.

The image is a photomicrograph of the nerve cell. The caption best describes the image.

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·June 17, 2013·4 min read

Researchers Develop Novel Drug That Reverses Loss of Brain Connections in Models of Alzheimer’s

Researchers have developed an experimental drug, NitroMemantine, to boost brain synapses lost in Alzheimer's disease. The drug stops the destructive cascade of brain changes which destroy connections between neurons that leads to memory loss and cognitive decline.

The image is a drawing of a brain slice with alzheimer's disease.

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·February 28, 2013·2 min read

New Model Could Lead to Improved Treatment for Early Stage Alzheimer’s

Using transgenic mice with specially designed gene fragments derived from bacteria and human cells, researchers were able to control the production of amyloid beta peptide using antibiotics.

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·January 15, 2013·2 min read

Major Step Toward an Alzheimer’s Vaccine

Researchers discovered a way to stimulate the brain's natural defense mechanisms in mice with Alzheimer's disease symptoms. This major breakthrough opens the door to the development of a treatment for Alzheimer's disease and a vaccine to prevent the illness.

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·October 22, 2012·3 min read

Clue to Alzheimer’s Cause Found in Brain Samples

Researchers found a key difference in the brains of people with Alzheimer’s disease and those who are cognitively normal but still have brain plaques that characterize this type of dementia.

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·August 15, 2012·5 min read

Scientists Discover Previously Unknown Cleansing System in Brain

A previously unrecognized system that drains waste from the brain at a rapid clip has been discovered by neuroscientists at the University of Rochester Medical Center and dubbed the glymphatic system.

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·July 24, 2012·4 min read

New Research Determines How a Single Brain Trauma May Lead to Alzheimer’s Disease

A study, performed in mice and utilizing post-mortem samples of brains from patients with Alzheimer’s disease, found that a single event of a moderate-to-severe traumatic brain injury (TBI) can disrupt proteins that regulate an enzyme associated with Alzheimer’s. The paper, published in The Journal of Neuroscience, identifies the complex mechanisms that result in a rapid and robust post-injury elevation of the enzyme, BACE1, in the brain. These results may lead to the development of a drug treatment that targets this mechanism to slow the progression of Alzheimer’s disease.