Researchers report ApoE4 can reduce the number of functional synapses by interfering with the DNA responsible for synapse formation and maintenance.
Impaired blood flow to specific areas of the brain coincides with Tau buildup in Alzheimer's patients. As cognition declines, the relationship between vascular dysfunction and Tau accumulation strengthens.
A new study reports Hispanic people not only tend to develop symptoms of Alzheimer's earlier than other racial groups, they also show earlier manifestations of neuropsychiatric symptoms associated with the disease.
Light exercise, such as walking, could offer hope for re-establishing some neural connections in people with MCI and Alzheimer's.
Researchers report on the other, often overlooked, symptoms of Alzheimer's disease.
Study in mice and humans reveals reinforcing the activity of microglia could slow, or potentially halt, the proliferation of Tau tangles in Alzheimer's disease.
Researchers have identified a specific signature of a group in genes in brain areas most vulnerable to Alzheimer's.
Mouse models and human brain tissue studies reveal microglia react to amyloid beta earlier in older females. Findings may provide avenues for the development of new drugs to help treat the neurodegenerative disease.
A new study published in brain reveals that just one night of sleep disruption causes an increase in amyloid beta in the brains of healthy, middle aged people. A full week of sleep disturbances leads to a build up of Tau, another protein associated with Alzheimer's and other neurodegenerative diseases. The study sheds light on why poor sleep has previously been associated with the development of Alzheimer's and other dementias.
According to researchers, the compound P7C3 may help to protect against neuron death and memory problems associated with Alzheimer's disease without altering the buildup of amyloid plaques or neurofibrillary tangles in rat brains.
Amyloid plaques form in the same location and spread in the same way in the brains of people with both obstructive sleep apnea and Alzheimer's disease.
Tau may be more directly instigating neuronal dysfunction than amyloid beta in Alzheimer's disease, a new study reports.
