A study that used postmortem brain tissue samples from Alzheimer's patients and mouse models found the hunger hormone ghrelin is linked to cognitive impairments and memory loss associated with the disease.
A 3D human tissue culture model demonstrated a possible causal relationship between Alzheimer's disease and herpes simplex virus 1 (HSV-1) infection. 40 Alzheimer's associated genes were over-expressed in the HSV-1 infected brain tissue, including genes associated with the production of amyloid-beta.
Reducing the expression of the protein TOM1 in mouse models of Alzheimer's disease increased the pathology, exacerbated cognitive problems, and raised levels of inflammation in the brain. Restoring TOM1 reversed the effects. Findings suggest a new therapeutic target for treating dementia.
Researchers discovered some protease inhibitors used to treat HIV can lead to the production of the peptide amyloid beta.
A new study sheds light onto a fundamental mechanism underlying the development of Alzheimer's disease. Researchers believe the findings could lead to new forms of therapy for those living with the disease.
A new study reports the dementia associated with Down syndrome involves defects in GSAP, which also malfunctions in Alzheimer's disease.
Researchers have developed a new technique to measure levels of amyloid beta in the brain. They have also discovered new insights into why mutations of the TREM2 gene increases the risk of developing Alzheimer's disease.