People with untreated depression have lower levels of mitochondrial proteins. For those who responded to the SSRI antidepressants, the proteins returned to a normal level, but showed no increase in those who did not respond to medication.
Combining deep-brain stimulation with intracranial EEG, researchers achieved an individualized understanding of specific brain networks that contributed to an individual's depression symptoms and identified stimulation patterns best suited to each patient for symptom relief.
A growing body of evidence suggests psychedelics including psilocybin and LSD show promise in providing lasting relief from symptoms for those suffering some mental health disorders. Researchers found DOI, a similar drug to LSD, reduced negative behavioral responses following fear triggers in mouse models of anxiety.
Researchers have determined the near-atomic scale structure of the anxiety-associated GPR158 receptor. The findings enable an avenue to create potential therapeutics to block the receptor in order to treat depression, stress, and other mental health disorders.
A new brain model explored bursts of human brain activity never before studied. The bursts may serve as potential biomarkers for depression, dementia, schizophrenia, and ADHD.
Mothers who use cannabis during pregnancy to relieve stress may be putting their children at risk of developing anxiety and stress later in life. Researchers found placental tissue revealed cannabis use in mothers was associated with lower expression of immune-activating genes. Cannabis suppression of placental immune-gene networks predicted higher anxiety in children.
Researchers report metacognition therapies, or directing personal thoughts and emotions for the benefit of mental wellbeing, can have positive effects on the treatment of anxiety, depression, and addictions.
Virtual reality is helping researchers uncover some of the secrets of anxiety. Using VR, study participants were able to distinguish between safe and dangerous environments in a game. However, brain scans of those with anxiety showed increased activity in the insula and dorsomedial prefrontal cortex while in a safe zone, indicating their brains were associating the safe environment with threat or danger.