Study reveals the surface features of human prions responsible for their replication in the brain. The findings provide a template to identify structurally important sites on other misfolded proteins, such as those associated with Alzheimer's disease.
P-glycoprotein, a critical toxin pump in the body, has the ability to remove amyloid plaques from the brain. Researchers say increasing P-gp in the blood-brain barrier of those at risk for Alzheimer's could postpone or prevent the onset of the neurodegenerative disease.
Study reveals the significant role lipids play in regulating the amyloid pathway protein C99 and the progression of Alzheimer's disease.
Elderly monkeys treated with CpG ODN had 59% fewer deposits of Alzheimer's related plaques in their brains compared to those who did not receive the treatment. The treatment also helped improve cognitive function and slow the progression of Alzheimer's symptoms.
A review of Alzheimer's research papers finds news media is more likely to report on breakthroughs if the study's authors omit a reference to mice in their title. Papers that acknowledge mice in their title receive less media coverage. Omitting mice from a paper's title generates twice the number of tweets than ones that mention the animals.
Combining artificial intelligence technology with data sets related to both Alzheimer's and COVID-19, researchers were able to identify a mechanism by which coronavirus can lead to Alzheimer's-like symptoms. The findings add to the growing body of evidence that COVID-19 infection can have lasting effects on brain function.
Researchers have identified three biomarkers in blood samples that confirm the link between exercise and improved cognitive function in older adults.
Researchers found tiny deposits of elemental copper and iron in the brains of Alzheimer's patients. The findings may shed new light on how these elemental metals contribute to Alzheimer's development and progression.
Sustained microglia activation leads to the cells becoming senescent. This leads to an accelerated accumulation of amyloid in the brain, influencing the early stages of Alzheimer's development.