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Alzheimer’s disease

·May 8, 2025·4 min read

HIV Drugs Linked to Lower Alzheimer’s Risk

New research shows that HIV drugs called NRTIs may significantly reduce the risk of developing Alzheimer’s disease. Analyzing two large health databases, scientists found that patients on NRTIs had a 6% to 13% annual decrease in Alzheimer’s risk.

Featured Neurology Neuroscience Psychology

·May 7, 2025·4 min read

Knowing Alzheimer’s Risk Lowers Anxiety, But Motivation Fades

A new study shows that learning about amyloid beta buildup — a risk factor for Alzheimer’s disease — does not increase emotional distress, but motivation to maintain healthy habits declines over time. Healthy adults who learned they had no amyloid buildup reported reduced depression, anxiety, and memory concerns, yet also lost motivation to continue positive lifestyle changes.

Featured Neurology Neuroscience

·May 7, 2025·9 min read

Want to Know Your Alzheimer’s Risk? Many Change Their Minds

New research reveals a striking gap between people’s theoretical desire to know their Alzheimer’s disease risk and their real-life decisions when results are actually offered. In a study of cognitively normal volunteers, only 60% chose to learn their estimated risk when given the chance, despite 81% expressing prior interest.

Featured Neurology Neuroscience

·April 28, 2025·3 min read

Immune Dysfunction May Drive Alzheimer’s Progression

A new study highlights a potential role for immune system dysfunction in the onset and progression of Alzheimer's disease. Researchers found that neuroinflammation, trained innate immune memory, and cellular reprogramming may interact with amyloid and tau proteins to drive disease pathology.

Featured Genetics Neurology Neuroscience

·April 25, 2025·7 min read

AI Uncovers New Cause of Alzheimer’s

Researchers have discovered that a gene previously seen as a biomarker for Alzheimer’s disease, PHGDH, actually plays a causal role by disrupting gene regulation in the brain. Using AI, the team revealed that PHGDH has a hidden DNA-binding function unrelated to its known enzymatic activity. This malfunction triggers early Alzheimer’s development, offering a new target for prevention.

This shows an older lady exercising and a brain.

Featured Neurology Neuroscience

·April 25, 2025·9 min read

Low and Moderate Exercise May Help Prevent Alzheimer’s Decline

New findings from the EXERT study reveal that both low and moderate-high intensity exercise may help preserve cognitive function in older adults with mild memory problems, a major risk factor for Alzheimer’s disease. Over 12 months, participants who engaged in either form of exercise showed significantly less cognitive decline and reduced brain volume loss, especially in the prefrontal cortex, compared to a usual-care group.

Neuroscience

·April 25, 2025·5 min read

Blue Brain Marker Peaks in Midlife, May Predict Cognitive Aging

Researchers have mapped age-related changes in the brain’s locus coeruleus (LC), a region linked to cognition and Alzheimer’s risk, by tracking neuromelanin, a pigment that gives it its signature blue hue. In a diverse group of participants aged 19 to 86, they found an inverted U-shaped pattern: LC signal peaked in late middle age, then declined.

Featured Neurology Neuroscience

·April 24, 2025·3 min read

Metabolic Syndrome in Midlife Linked to Higher Dementia Risk

A large-scale study has found that having metabolic syndrome in midlife—marked by excess belly fat, high blood pressure, and abnormal cholesterol or blood sugar—is associated with a significantly higher risk of developing young-onset dementia before age 65. The analysis, based on nearly two million people, showed that the more components of metabolic syndrome a person had, the greater their dementia risk, with women and those in their 40s being most vulnerable.

Featured Neurology Neuroscience

·April 24, 2025·5 min read

Experimental Alzheimer’s Vaccine Shows Promise

Researchers have developed a tau-targeting vaccine that could help prevent the progression of Alzheimer’s disease by generating a strong immune response against abnormal tau proteins. The vaccine showed effectiveness in mice and non-human primates, prompting researchers to pursue human clinical trials.

Featured Genetics Neurology Neuroscience

·April 22, 2025·5 min read

Microglia Reprogrammed to Deliver Precision Alzheimer’s Therapies

Researchers have developed engineered human microglia that detect disease-related brain changes and release therapeutic proteins precisely where needed. Using CRISPR technology, the team programmed these cells to secrete an enzyme that breaks down beta-amyloid plaques only in affected areas.

Featured Neurology Neuroscience

·April 21, 2025·6 min read

Early Alzheimer’s Clues Found in Adults as Young as 24

A new study reveals that cognitive changes tied to Alzheimer's risk factors begin far earlier in life than previously thought, some as early as age 24. Researchers found associations between memory performance and cardiovascular risk factors, immune markers, and Alzheimer’s biomarkers (amyloid, tau, and neurodegeneration) in individuals aged 24–44.

This shows a brain and the outline of a person.

Featured Genetics Neurology Neuroscience

·April 17, 2025·3 min read

How Age, Sex, and Genetics Shape Blood Biomarkers for Dementia

A new study reveals how age, sex, menopause, and genetics influence key blood biomarkers linked to dementia risk. Researchers analyzed data from over 1,000 people, measuring three biomarkers over a 17-year period and comparing results between those who developed dementia and those who did not.

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Alzheimer’s disease

HIV Drugs Linked to Lower Alzheimer’s Risk

Knowing Alzheimer’s Risk Lowers Anxiety, But Motivation Fades

Want to Know Your Alzheimer’s Risk? Many Change Their Minds

Immune Dysfunction May Drive Alzheimer’s Progression

AI Uncovers New Cause of Alzheimer’s

Low and Moderate Exercise May Help Prevent Alzheimer’s Decline

Blue Brain Marker Peaks in Midlife, May Predict Cognitive Aging

Metabolic Syndrome in Midlife Linked to Higher Dementia Risk

Experimental Alzheimer’s Vaccine Shows Promise

Microglia Reprogrammed to Deliver Precision Alzheimer’s Therapies

Early Alzheimer’s Clues Found in Adults as Young as 24

How Age, Sex, and Genetics Shape Blood Biomarkers for Dementia

Gene Key to MS Immune Regulation Discovered

Maternal Depression Linked to Weaker Bonds

Study Challenges Link Between Football and Brain Protein Buildup

Spotting Silent Scars: A New Way to Detect Childhood Abuse

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