Genetic risk score for bipolar disorder is associated with an increased risk of developing bipolar symptoms. The genetic risk factor for schizophrenia is linked to an increased risk of those with depression developing psychosis. Read More
Bipolar disorder affects about 1% of the population and typically begins during adolescence. Researchers explain the biological, psychological, and behavioral implications of bipolar disorder. Read More
Comparing data from multiple neuroimaging studies, researchers found shared brain structural abnormalities between four psychiatric disorders, including schizophrenia and bipolar disorder. They also identified brain signatures unique to each condition. Read More
A worldwide scientific collaboration has produced the first genetic map of the cerebral cortex. The map identifies more than 300 genetic variants that influence cortical structure and play roles in psychiatric disorders. Read More
The largest genetic map of mental health disorders to date reveals there are three groups of highly genetically related disorders among eight psychiatric disorders. A gene related to nervous system development is a risk factor for all eight disorders studied. The RBFOX1 gene is implicated in seven of the eight disorders. ADHD and depression share 44% of genetic risk factors common in the general population. 109 pleiotropic loci affect more than one disorder. These pleiotropic loci are within genes that show heightened expression in the brain through the lifespan, beginning during the second trimester of pregnancy. Read More
A recent case study report highlights the effects of LSD overdoses on three women, revealing the subjects experienced improvements in physical and mental health following their overdoses. Read More
Computer analysis of patients reveals five clearly defined subgroups of psychosis and bipolar disorder. Those in group two were more likely to exhibit suicidal tendencies, while those in group five, for example, were characterized by schizophrenia diagnosis and lower verbal intelligence scores. Defining the characteristics of the subtypes could lead to improved personalized treatments for psychosis related mental illnesses. Read More
Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder. Read More
Those with 22q11.2 deletion syndrome had significantly lower brain volume, as well as lower volumes in specific structures, including the thalamus, hippocampus, and amygdala. Read More
Lower levels of the circular RNA in the frontal cortex appears to be correlated with earlier onset of schizophrenia symptoms. Read More
Daily exposure to bright, artificial light may help reduce symptoms of bipolar disorder. Read More
Study reports a slightly elevated genetic risk of depression, schizophrenia, and neuroticism among adoptees. However, no association was found between the interaction of genetics and adoption on mental health. While adopted children had a slightly elevated risk for mental health disorders, the adoption process did not appear to increase the impact of the genetic risk. Read More
