Patients with schizophrenia, but not those with social anhedonia, exhibited deficits in real-life social network size. Those with schizophrenia and those with social anhedonia had reversals functional connectivity to one another. People with schizophrenia showed decreased segregation and functional connectivity in brain areas associated with social behaviors, while those with social anhedonia had an increase in connectivity and segregation.
Prescribing SSRIs during late childhood to those with genetic risk factors for psychosis can reduce the deterioration of intellectual abilities, a new study reveals. SSRIs appear to have a neuroprotective effect for certain brain areas associated with the onset of psychosis if provided early.
Adolescents with higher levels of Omega 3 fatty acids in their blood had a decreased risk of developing psychosis as they entered into early adulthood. At the age of 24, those with psychosis had lower levels of DHA than those without the disorder.
Medications with anticholinergic properties given to help reduce physical and mental health symptoms associated with schizophrenia have a cumulative effect in reducing cognitive function in patients.
Flies without the Rim gene or cac Cav2 channel function displayed numerous cognitive and behavioral deficits associated with schizophrenia, and had reductions in synaptic growth and neural calcium transients. Exposing the flies with Rim deficits to the common antipsychotic haloperidol reduced some of the schizophrenia-related behavioral symptoms.
A link has been identified between psychosis and a genetic change that alters the immune system in the brain. Researchers found people with psychosis associated with bipolar disorder had decreased expression of GRK3. This led to an increased amount of kynurenic acid in the brain.
Almost fifty percent of people who have children with partners suffering from schizophrenia or bipolar disorder also have mental health challenges, a new study reports.
Adolescents with a higher risk for developing psychosis have subtle differences in brain structure, including lower cortical thickness than their peers without risk factors. In those who developed psychosis, the cortical thinning was most pronounced in several areas of the temporal and frontal regions of the brain.
Researchers have implicated alterations in the balance of two chloride ion channels in the cognitive deficits associated with schizophrenia. Inhibiting transporter activity with bumetanide reversed some of the cognitive symptoms in mouse models of the psychiatric disorder.
People with schizophrenia and other neuropsychiatric disorders may have a more permissive blood-brain barrier which allows the immune system to become more actively involved in the central nervous system. The resulting inflammation may contribute to the clinical manifestation of psychosis-like symptoms.
Betaine, a dietary supplement extracted from sweet beets, reduces behavioral symptoms of schizophrenia in mice with genetic risk factors for the disorder. The supplement may help protect proteins that build the cellular skeletons of neurons.