Schizophrenia

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How are psychiatric disorders linked to infections during pregnancy?

Previous studies have documented how infection during pregnancy can increase the risk of ASD and a range of psychiatric disorders in the offspring. A new study reveals how maternal infections can affect neural development and how the timing of infection plays a critical role in elevating the risks of mental health conditions.... Read More...
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Biomarker for schizophrenia can be detected in human hair

Mouse models and human postmortem brain tissue sample studies reveal a subtype of schizophrenia is related to abnormally high levels of hydrogen sulfide in the brain. Hair follicle analysis of patients with this schizophrenia subtype revealed higher expression of MPST mRNA than in those without the condition. MPST is linked to the production of hydrogen sulfide. The findings may lead to new tests to determine if a patient has the schizophrenia subtype from a simple hair sample analysis.... Read More...
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Scientists reverse core symptom of schizophrenia in adult mice

Neuronal branches in SETD1A deficient mice are shorter and stunted. Switching off another gene, LSD1, nullifies the harmful effects of SETD1A on neuron and axon growth. After inhibiting LSD1, SETD1A deficient mice showed improved memory and axon growth. Inhibiting LSD1 not only acted on memory deficits linked to schizophrenia but also acted on the underlying molecular mechanisms associated with axonal growth. ... Read More...
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The propensity to hear ‘voices’ in Schizophrenia may be established by infancy

People with schizophrenia who experience auditory hallucinations have greater activation in specific areas of the auditory cortex in response to sound frequencies. The mapping of sound frequency in the auditory cortex is scrambled in those with schizophrenia, suggesting a disruption in the normal processes for organized sound representation in the brain. As the tonotopic map is established during infancy and remains stable throughout life, the findings suggest vulnerability for auditory hallucinations is linked to defects in the organization of the auditory system during infantile development. This precedes speech development and the onset of psychiatric symptoms.... Read More...