Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.
Male children with isolated GnRH deficiency (IGD), a rare endocrine disorder associated with a lack of sex hormone during the second trimester of development, report more gender non-conformity than males without IGD. The same was not true for females with IGD.
People with ADHD had a 34% higher risk of developing dementia than those without the disorder. The risk of being diagnosed with Alzheimer's, the most common type of dementia, was 55% higher for those with ADHD.
Researchers have identified 2,000 genes in humans linked to longevity. The genes are associated with biological mechanisms that drive the prolongation of life in mammals, including DNA repair, coagulation, and immune response.
A new, open access repository incorporates frequently asked questions and answers by genomics researchers to provide a better general understanding of what their studies do, and do not show.
Almost half of the identified human accelerated regions of the genome appear to act as neurodevelopment enhancers, researchers say. The findings shed new light on the genetic basis of human evolution.
Despite the Y chromosome containing very few genes, it can dramatically alter male body size and may facilitate the evolution of sex differences.
A new study reveals there appears to be a neurobiological component that drives instantaneous compatibility, in mice at least. A variation of the PDE11 enzyme found in brain areas governing mood and motivation seems to control whether mice want to socially interact or not, with genetically similar mice preferring each other.
Researchers have identified 579 genetic loci associated with increased risk of disorders associated with self-regulation disorders including addiction, ADHD, and anti-social behavior.
Long-term circadian rhythm disruptions induce Alzheimer's disease-like pathology in rats, which can be reversed by administering fluoxetine. Additionally, elevated levels of amyloid beta and circadian rhythm disruptions can trigger each other, leading to the cascade of neurological symptoms of dementia.