Transplanted brain stem cells survive without anti-rejection drugs
Researchers have developed a new method to transplant neural stem cells into mice without the need for lifelong anti-rejection medications.... Read More...
Genetics
Genetics articles related to neuroscience research will be listed here.
A new approach for treating inflammation
Targeting the miR-199, a microRNA which reduces the migration of neutrophils could potentially reduce inflammation without compromising the immune system.... Read More...
How lymphoma cells metastasize to the brain
In aging mice, chronic inflammatory processes lead lymphoma cells which entered the brain to be retained, rather than released directly back into the blood.... Read More...
Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells
APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.... Read More...
Brain activity intensity drives need for sleep
Galanin expressing neurons are selectively active during rebound sleep. The expression of galanin increases after neuronal activity and sleep deprivation. The neuropeptide plays a critical role in sleep homeostasis.... Read More...
How the eyes might be windows to the risk of Alzheimer’s disease
Adults with mild cognitive impairment (MCI), a precursor to Alzheimer's disease, have greater pupil dilation when taking cognitive tests than their cognitively normal peers. Task-evoked pupillary response may be a cost-effective, and low invasive screening test for those at genetic risk for Alzheimer's before the symptoms of the disease take hold. ... Read More...
Scientists identify gene as master regulator in schizophrenia
TCF4 may serve as a master regulator of a gene network dysregulated in schizophrenia at the early stages of neurodevelopment.... Read More...
Is laziness a choice or genetic trait?
Study identifies a specific gene in rats that relates to physical inactivity. The gene could play a role in human sedentary behaviors.... Read More...
Genes associated with left-handedness linked with shape of the brain’s language regions
Four genetic regions have been identified as playing a role in left-handedness. Three of the four genes were associated with proteins involved in brain development and structure. Neuroimaging revealed those who were left-handed had increased functional connectivity between left and right language networks. Researchers also found correlations between the genetic regions associated with left-handedness and slightly reduced Parkinson's risk, but a slightly increased risk for schizophrenia.... Read More...
New insight into motor neuron death mechanisms could be a step toward ALS treatment
When a motor neuron-specific pool of heat shock protein 90 (Hps90) was inhibited, motor neuron apoptosis was triggered.... Read More...
Receptor protein in brain promotes resilience to stress
S1PR3, a receptor found on the surface of brain cells, may play a key role in stress resilience. Veterans with severe PTSD symptoms had lower levels of the S1PR3 protein in their blood than peers without the disorder. ... Read More...
The neurobiological mechanisms behind schizophrenia may depend on gender
Schizophrenia is linked to alterations in pathways associated with glycosaminoglycan, neurotransmitter metabolism, and GABAergic synapses. A large percentage of genes related to schizophrenia are expressed differently between males and females. The results imply the mechanisms involved in schizophrenia development differ, at least slightly, between males and females.... Read More...