The FMNL2 gene links cerebrovascular disease and Alzheimer's disease, a new study reports. Changes of activity in the FMNL2 caused by cerebrovascular disease prevent the efficient cleaning of toxic proteins in the brain, leading to the development of Alzheimer's disease.
From keeping active and eating a healthy diet to controlling cholesterol and reducing sugar intake, researchers report on seven simple lifestyle changes older adults with genetic risk factors can make to reduce the chance of developing dementia.
Researchers have identified a mechanism shared by mutations in the SHANK3 and ADNP genes. The genes have been associated with the development of ASD and schizophrenia.
Hypermutation in children may be linked to increased mutations in the sperm of the biological father, especially fathers who received certain forms of chemotherapy to treat cancer early in life.
Researchers have designed a new method of converting non-neural cells into functioning neurons that are able to form synapses, dispense dopamine, and restore the function of neurons undermined by Parkinson's associated destruction of dopaminergic cells.
INSR, a protein essential for insulin activity, plays a critical role in stem cell longevity. Additionally, inactivating INSR in glioblastoma brain cancer stem cells inhibits the growth of primitive tumor forming cells.
Study reports an overlap between genetic architecture and co-morbid mental health diagnosis. Researchers found 70% of the genetic signals associated with schizophrenia were also linked to bipolar disorder. Anorexia and OCD have a strong, shared genetic architecture.