Mutations of the ATG4D gene which is associated with autophagy have been linked to a rare neurological disorder in children that causes a range of motor coordination and speech problems.
Researchers have identified 27 new gene variants associated with the development of ADHD.
Researchers investigate how the gut microbiome may impact brain development and contribute to neurodevelopmental disorders including ASD and ADHD.
Musicians and musically active people tend to have a higher genetic risk factor for bipolar disorder and depression, a new study reports.
In older adults, major depression has been linked to mitochondrial deterioration.
Calcium signaling was found to be a central abnormality in schizophrenia neurons. Targeting calcium signaling in neurons could be a potential new way to treat the 16p11.2 duplication variation of schizophrenia.
The interaction of Tau with RNA is a key stage in the development of Alzheimer's disease and other dementias.
Brain organoids created from human stem cells that were transplanted into the brains of rats responded to visual stimuli.
Study reveals a previously unknown genetic link between increased blood platelet distribution and an increased risk of developing Parkinson's disease.
Natural resistance to capsaicin's effect in birds drove researchers to investigate a specific genetic variant that appears to be associated with pain resistance. They discovered the K710N human variant dialed down pain associated with capsaicin while enhancing the protective benefits of TRPV1. The findings could pave the way for the development of new treatments to manage pain.
CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.
Paternal exposure to chemicals in plastics can affect the metabolic health of offspring for two generations, a new study reports. Parental exposure to DCHP leads to higher resistance and impaired insulin signaling in both the first and second generations of offspring.
