The Parkinson's-associated protein alpha-synuclein appears to act as a "toggle switch" that helps control vesicle transportation and gene expression. In a diseased state, this delicate balance is broken. The findings have implications for the development of new treatments for Parkinson's disease.
Researchers have identified the cellular and molecular mechanisms that regulate selective autophagy.
A new study sheds light on how the neocortex in the human brain develops.
Genetic factors influence the severity of symptoms in children on the autism spectrum, and different genetic factors were associated with different symptoms of ASD.
Sex-specific circuits in muscles signal to other tissues and organs, processing muscle impact differently in males and females.
The FMNL2 gene links cerebrovascular disease and Alzheimer's disease, a new study reports. Changes of activity in the FMNL2 caused by cerebrovascular disease prevent the efficient cleaning of toxic proteins in the brain, leading to the development of Alzheimer's disease.
From keeping active and eating a healthy diet to controlling cholesterol and reducing sugar intake, researchers report on seven simple lifestyle changes older adults with genetic risk factors can make to reduce the chance of developing dementia.
Researchers have identified a mechanism shared by mutations in the SHANK3 and ADNP genes. The genes have been associated with the development of ASD and schizophrenia.
A new study sheds light on the biological mechanism behind some genetic forms of epilepsy.
AZD1236, an existing drug used primarily for the treatment of COPD, reduces damage following spinal cord injury by inhibiting the inflammatory response in the spinal cord.
Researchers have identified ten novel genes and changes in the stria vascularis that appear to be associated with age-related hearing loss.
Study implicates the gene DJ1 in neuronal death associated with Parkinson's disease.