Stem cells derived neurons integrate well into the correct regions of the brain, connecting with native neurons and restoring motor function in mouse models of Parkinson's disease. Read More
Parkinson's disease can be divided into two variants that start in different places in the body. For some, the neurodegenerative disease starts in the intestines and spreads to the brain. In others, the disease begins in the brain and spreads to the intestines and other organs. Read More
Study suggests an alternative strategy for restoring cellular abnormalities in in-vitro models of Parkinson's disease. Read More
Anticholinergic medications, commonly used for conditions including allergies, high blood pressure, Parkinson's disease, and motion sickness, have been linked to an increased risk of cognitive decline and memory problems, especially in those with genetic risk factors for Alzheimer's disease. Read More
Neurons can counteract degeneration and promote survival by adapting their metabolism. Read More
Researchers have discovered a series of misfolded alpha-synuclein protein structures never previously observed. The alpha-synuclein fibers were larger than previously reported and adopted a striking variety of shapes. The work lays the foundation for a detailed analysis of misfolded alpha-synuclein structures and could provide a better understanding of the neurobiology of Parkinson's disease. Read More
Eating a diet rich in vegetables and nuts during middle age is linked to fewer symptoms that may precede Parkinson's disease. Read More
Researchers administered PTB antisense oligonucleotide treatment directly to the midbrain of mice. In the mouse models exposed to the treatment, a small subset of astrocytes converted to neurons, increasing the number of neurons by 30%. Three months after treatment, mice were completely free of Parkinson's disease symptoms and remained in remission for the rest of their lives. Read More
Circadian rhythm disruptions in older men have been linked to an increased risk of developing Parkinson's disease. The findings suggest circadian disruptions may reflect the neurodegenerative processes already affecting the brain's internal clock prior to the diagnosis of Parkinson's. Circadian disruptions, researchers say, could be considered an early warning sign of Parkinson's. Read More
Researchers have uncovered the process by which air pollution can damage brain cells, leading to an increased risk of Parkinson's disease. Chemicals found in diesel fuel reduced autophagic flux, which is a major pathway implicated in neurodegeneration. Read More
Dopamine receptors have different molecular features and functions depending on their anatomical location within the striatum. The findings could help develop better-targeted treatments for a range of disorders from schizophrenia to Parkinson's disease. Read More
Involuntary movements and tremors caused as a result of taking dopamine replacement medications for Parkinson's disease can be alleviated through the suppression of RasGRP1. Read More
