Parkinson’s disease

Latest

Parkinson’s disease

·June 24, 2020·6 min read

One-time treatment generates new neurons and eliminates Parkinson’s disease

Researchers administered PTB antisense oligonucleotide treatment directly to the midbrain of mice. In the mouse models exposed to the treatment, a small subset of astrocytes converted to neurons, increasing the number of neurons by 30%. Three months after treatment, mice were completely free of Parkinson's disease symptoms and remained in remission for the rest of their lives. Read More

Featured Neurology

·June 15, 2020·7 min read

Disrupted circadian rhythms linked to later Parkinson’s diagnoses

Circadian rhythm disruptions in older men have been linked to an increased risk of developing Parkinson's disease. The findings suggest circadian disruptions may reflect the neurodegenerative processes already affecting the brain's internal clock prior to the diagnosis of Parkinson's. Circadian disruptions, researchers say, could be considered an early warning sign of Parkinson's. Read More

Featured Neurology Neuroscience

·May 20, 2020·4 min read

Link between diesel exhaust and risk of Parkinson’s discovered

Researchers have uncovered the process by which air pollution can damage brain cells, leading to an increased risk of Parkinson's disease. Chemicals found in diesel fuel reduced autophagic flux, which is a major pathway implicated in neurodegeneration. Read More

This shows different d2rs in the striatum

Featured Neurology Neuroscience Open Neuroscience Articles

·May 13, 2020·3 min read

Significant differences exist among neurons expressing dopamine receptors

Dopamine receptors have different molecular features and functions depending on their anatomical location within the striatum. The findings could help develop better-targeted treatments for a range of disorders from schizophrenia to Parkinson's disease. Read More

This shows a person holding a cup of wateri

Featured Genetics Neurology Neuroscience

·May 1, 2020·5 min read

Parkinson’s dyskinesia mechanism explained

Involuntary movements and tremors caused as a result of taking dopamine replacement medications for Parkinson's disease can be alleviated through the suppression of RasGRP1. Read More

Featured Neurology Neuroscience Open Neuroscience Articles

·April 30, 2020·3 min read

Researchers unravel protein mystery of three brain diseases

Researchers have identified two different shapes of alpha-synuclein associated with multiple systems atrophy (MSA) and Lewy body dementia. The structure of the protein is helical in MSA, causing the symptoms to occur more quickly and aggressively. In Lewy body dementia, the protein takes on a cylindrical form. Read More

Featured Genetics Neurology Neuroscience

·April 27, 2020·3 min read

More evidence Parkinson’s disease may start in the gut

Enteric neurons appear to play a key role in the development of Parkinson's disease. The findings support the hypothesis and previous studies that the neurodegenerative disease may start in the gut before spreading to the brain. Researchers also found oligodendrocytes were affected during the early stages of Parkinson's, even before the loss of dopaminergic neurons. Read More

Featured Neurology Neuroscience Open Neuroscience Articles

·April 20, 2020·4 min read

Further evidence autoimmunity plays a role in Parkinson’s disease

T cells that react to alpha-synuclein are most abundant in the early stages of Parkinson's disease but tend to disappear as the disease progresses. Signs of autoimmunity can appear in Parkinson's patients up to ten years before a diagnosis of the neurodegenerative disease. The detection of T cell response could be an early biomarker for Parkinson's, long before the physical symptoms begin to manifest. Read More

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·April 14, 2020·4 min read

Being “right-brained” or “left-brained” comes down to molecular switches

Epigenetic regulation controls whether certain genes on each side of the brain are switched on or off. The findings shed light on why Parkinson's disease often affects one side of the body before the other. Read More

Closeup images of neurons with markers labeled shown.

Featured Genetics Neuroscience

·March 26, 2020·3 min read

Jumping Genes Help Make Neurons in a Dish

Converting skin cells to functional brain cells relies on precise insertion of Line-1 retrotransposons. Read More

Featured Genetics Neuroscience

·March 20, 2020·3 min read

Worldwide Study Unlocks Genetic Secrets of the Gray Matter

Researchers have created the first genetic map of the cerebral cortex, which identifies over 300 genetic variants that influence the structure of the brain region. Read More

Featured Neurology Neuroscience

·March 13, 2020·5 min read

‘Natural killer’ cells could halt Parkinson’s progression

Natural killer cells may play a critical role in regulating and restraining neuroinflammation and protein clumping associated with Parkinson's disease. Read More

1 2 3 … 52