Researchers identified two genes that respond to age-related iron accumulation in the substantia nigra. Knockdown of these genes results in severely impairing the cellular tolerance for iron toxicity.
Adding to previous research on the gut-brain axis link to Parkinson's disease, researchers discovered the gut microbiome is involved with multiple pathways in the pathogenesis of Parkinson's.
Krill oil protects dopaminergic neurons from age-related degeneration, decreases alpha-synuclein aggregation, and improves dopamine-dependent cognition and behavior in lab models of Parkinson's disease.
People who lost weight soon after being diagnosed with Parkinson's disease had a more rapid decline in thinking skills compared to those who maintained their normal weight. Those who gained weight had a slower decline in cognitive skills.
Post-mortem analysis of the brains of those with Parkinson's disease revealed more than 200 genes with different epigenetic markers compared to healthy brains, but the affected genes were almost entirely different between women and men.
Researchers discovered personal odors can alter in people with Parkinson's disease. Based on this, they identified specific markers for Parkinson's in sebum, an oily substance secreted from the skin. They developed a new, non-invasive swab test that can identify Parkinson's with 95% accuracy.
A new in-home device that monitors movement and gait speed can evaluate Parkinson's disease severity, progression, and a patient's response to medication.
Researchers successfully turned skin cells from Parkinson's patients into dopaminergic neurons by introducing a combination of neural-inducing genes into the skin cells.
COVID-19 infection has been linked to a range of lasting neurological and psychological disorders, including depression, memory problems, and Parkinson's-like disorders, within the first year following infection.