Gut Bacteria Interferes with Metabolism of Parkinson’s Drug
Study provides first concrete examples of how the microbiome can interfere with a drug's intended path throughout the body.... Read More...
Parkinson’s disease
Ultrasound method restores dopaminergic pathway in brain at Parkinson’s early stages
Using transcranial focused ultrasound in combination with injectable microbubbles, researchers open a pathway through the blood-brain barrier. The technique allows drugs to penetrate the brain and trigger therapeutic effects for those with neurodegenerative diseases.... Read More...
Newly discovered mechanism reveals how Parkinson’s disease can spread between brain cells
Connexins play a critical role in the uptake and transfer of Parkinson's related proteins from one cell to another. The findings may help with the development of new treatments for Parkinson's disease.... Read More...
Bipolar disorder may be linked to Parkinson’s disease
People with bipolar disorder have higher incidences of Parkinson's disease than those without the psychiatric condition. Manic and depressive episodes were associated with an elevated risk of developing Parkinson's disease. ... Read More...
Noninvasive biomarker for Parkinson’s disease possibly found in EEG data
Using EEG to measure beta waves shows promise in detecting Parkinson's disease in a non-invasive way.... Read More...
Researchers link new protein to Parkinson’s
The MITOL protein has been implicated in Parkinson's disease. ... Read More...
Miro2 is a Parkin receptor for selective removal of damaged mitochondria
Findings from a mouse model study reveal Miro2 functions as a platform for Parkin translocation and damaged mitochondrial clearance. ... Read More...
Inflamed monkey guts produce Parkinson’s-related proteins
Inflammation of the colon is associated with alterations in alpha-synuclein expression and phosphorylation in the myenteric plexus of common marmoset monkeys. The findings support the growing body of evidence that inflammation may play a role in the development of Parkinson's disease.... Read More...
Appendix removal associated with development of Parkinson’s disease
Using data collected from 62.2 million Parkinson's patients, researchers discover a relationship between appendectomies and an increased risk of developing the disease. According to the analysis, patients who had their appendix removed were more than three times as likely to develop Parkinson's than those who had not.... Read More...
New method developed to target cause of Parkinson’s
Clioquinol, an anti-parasitic medication, overcomes the effect of mutations in the LRRK2 gene associated with Parkinson's disease by restoring the acidity of lysosomes and clearing out protein aggregates. ... Read More...
Poor sense of smell associated with nearly 50% higher risk for death in 10 years
Poor olfaction is correlated with higher long-term mortality in older adults, particularly in those with good health at baseline. Dementia, Parkinson's disease and weight loss may be possible drivers for the higher mortality rates, but around 70% of cases are unexplained. ... Read More...
Blood pressure drug shows promise for treating Parkinson’s and dementia in animal study
Felodipine, a common hypertension medication, induces autophagy and clears aggregate-prone proteins associated with neurodegenerative diseases. The study reveals the drug clears mutant alpha-synuclein in the brains of mice at plasma concentrations to those seen in humans taking the medication. Felodipine appears to have some neuroprotective properties in mouse models of neurodegenerative diseases.... Read More...