Researchers have discovered a series of misfolded alpha-synuclein protein structures never previously observed. The alpha-synuclein fibers were larger than previously reported and adopted a striking variety of shapes. The work lays the foundation for a detailed analysis of misfolded alpha-synuclein structures and could provide a better understanding of the neurobiology of Parkinson's disease.
Activating Nrf2 helps with the removal of LRRK2 and alpha synuclein, researchers report.
Study implicates abnormalities in SOD1 with Parkinson's disease and ALS.
Anticholinergic drugs, commonly prescribed to treat a range of disorders, from Parkinson's disease to bladder conditions, may increase dementia risks. The increased risk was linked to anticholinergic antidepressants, antipsychotics, bladder control, epilepsy and Parkinson's disease medications. There were no increased risks associated with other types of anticholinergics, such as gastrointestinal drugs or antihistamines.
Researchers report people with PSP experience more severe and extensive cognitive impairments than those with Parkinson's disease.
Study reveals patients with bipolar disorder have a significantly increased risk of developing Parkinson's disease compared with the general population.
N-acetylcysteine appears to help enable dopamine neurons to recover some function, researchers report.
Researchers have mapped out a circuit of neurons responsible for motor impairment in Parkinson's disease patients.
A new study reveals information about life expectancy for those with Parkinson's and other synucleinopathies.
Using electrochemical probes transplanted into living human brains, researchers shed light on how serotonin acts.