Researchers identified LIPE, a lipase that degrades triglycerides to produce fatty acids, as a potential new target for the development of treatments for Parkinson's disease.
Focusing on the largest pyramidal neurons in the motor cortex, researchers found dendritic branches do not simply pass movement information forward. Each sub-branch calculates the information and passes it to larger sub-branches, which in turn, perform the same operation. Multiple dendritic branchlets can interact with each other to amplify their combined computational product.
The Parkinson's-associated protein alpha-synuclein appears to act as a "toggle switch" that helps control vesicle transportation and gene expression. In a diseased state, this delicate balance is broken. The findings have implications for the development of new treatments for Parkinson's disease.
Older adults who frequently experience bad dreams or nightmares are twice as likely to be diagnosed with Parkinson's disease, a new study reports.
Neurons in the parafascicular thalamus project to three different parts of the basal ganglia. Targeting these circuits could be a new target for treating motor dysfunction and depression associated with Parkinson's disease.
A newly invented soft, implantable probe can interface between gut and brain tissue, measuring both dopamine and serotonin levels. The device has applications for depression, Parkinson's disease, and intestinal disorders.
A new mouse study reveals our sleep position may influence the glymphatic system and could increase the risk of developing ALS or other neurodegenerative diseases.
Volume decreases in cortical areas, the amygdala, and basal forebrain in Parkinson's patients correlated with worsening symptoms of the disease.
A new computer model shows the beneficial effects of deep brain stimulation arise from how it interrupts the cycle promoting runway beta in a circuit loop between the subthalamic nucleus and striatum.
Researchers have designed a new method of converting non-neural cells into functioning neurons that are able to form synapses, dispense dopamine, and restore the function of neurons undermined by Parkinson's associated destruction of dopaminergic cells.