neurobiology

This diagram shows how a-synuclein travels from the gut to the brain via the vagus nerve

New research shows Parkinson’s disease origins in the gut

A new study adds to the growing body of evidence that Parkinson's disease may start in the gut. Researchers found gut-to-brain propagation of alpha-synuclein spread via the vagus nerve. The study provides a more accurate model of Parkinson's progression and could lead to new treatments to halt or prevent this neurodegenerative disease.... Read More...
This shows a person with pills in their hand

Common antidepressants interact with opioid med to lessen pain relief

SSRI antidepressants, such as Prozac and Paxil, interact with opioid medications to make them less effective at providing relief from chronic pain. Tramadol relies on activation of the CYP2D6 enzyme to control pain, but SSRIs inhibit this enzyme. Researchers suggest prescribing different classes of antidepressants which do not suppress the enzyme may benefit those in need of opioid medications. Alternatively, non-opioid pain killers should be considered for those who can not switch from SSRIs.... Read More...