Researchers say estimates of how strongly diseases and traits share genetic signals could be over-inflated. Instead, they suggest, mating patterns may help explain the biological relationship between traits.
When people carry the Alzheimer's associated APOE4 gene, oligodendrocytes fail to transport fatty molecules to wrap neurons that make brain circuitry connections. This deficit of myelin may contribute to the pathology and symptoms of Alzheimer's disease.
The developmental onset of puberty is dependent upon the TBX3 gene, a new study reports. Researchers also found puberty onset is linked to neural differentiation during the development of the hypothalamus.
The loss of the Arid1b gene interferes with brain cells implicated in signaling inhibition. Reduced inhibitory signaling has previously been associated with a range of autism-related behaviors.
Muscle weakness marked by grip strength was associated with accelerated biological aging, a new study reports.
Researchers have identified 134 genes associated with autism and a range of genetic alterations associated with ASD. Notably, the study identified changes in copy number variations with likely associations with ASD, including autism-associated variants in 14% of people on the autism spectrum.
The epigenetic clocks of those who indulged in unhealthy behaviors as teens were 1.7 to 3.3 years older than individuals who reported more healthy lifestyles as teens.