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Alzheimer’s disease

·May 28, 2026·9 min read

Neuronal AcCoA Signaling Linked to Autophagy Defects in Alzheimer’s

Neurons and glial cells utilize a specialized metabolic mechanism centered on leucine-derived acetyl-coenzyme A (AcCoA) to regulate the master growth hub, mTORC1.

Featured Genetics Neurology Neuroscience

·May 20, 2026·10 min read

Alzheimer’s Risk Gene May Drive Aggressive ALS

The APOE ε4 variant heavily influences how toxic phosphorylated TDP-43 (pTDP-43) pathology migrates across the central nervous system.

$This shows a brain made of pills.$

Featured Neurology Neuroscience

·May 18, 2026·9 min read

New Math Method Inflates Alzheimer’s Drug Success by 29x

A critical research lette exposes severe flaws in "quantile aggregation", a statistical technique recently used by pharmaceutical researchers to evaluate the drug donanemab.

Featured Neurology Neuroscience

·May 18, 2026·8 min read

Parkinson’s Drug Restores Memories in Alzheimer’s

Severe dopamine dysfunction in the entorhinal cortex is a primary, hidden mechanism behind Alzheimer's-related memory impairment. Researchers found that dopamine levels in this vital memory gateway drop to less than 20% of normal, causing localized neurons to stop encoding memories altogether.

Featured Neurology Neuroscience

·May 18, 2026·8 min read

Poor Sleep Linked to Alzheimer’s Risk

A new study researchers demonstrates that self-reported poor sleep is directly associated with worse visual memory and accelerated tau protein accumulation in older women, but only those with a high genetic risk.

Featured Neurology Neuroscience

·May 16, 2026·8 min read

Overall Brain Health Protects Memory From Early Alzheimer’s

Why do some brains withstand the earliest onslaught of Alzheimer’s disease without showing cognitive decline? A new study demonstrates that maintaining good overall brain health can actively defend memory, attention, and executive function from early Alzheimer’s-related pathology.

Featured Neurology Neuroscience

·May 15, 2026·7 min read

Rogue Antibodies Drive Tau Pathology

A new study establishes a direct causal link between IgLON5 antibodies and Tau pathology. By applying patient antibodies to mouse models, the team discovered that antibody-induced clustering of cell-surface IgLON5 proteins sparks profound neuronal hyperactivity.

This shows an older woman sleeping and microglia.

Featured Neurology Neuroscience

·May 12, 2026·6 min read

Targeting Brain “Clean-up” Cells to Fight Dementia

Researchers discovered that dysregulated circadian rhythms cause microglia, the brain’s immune cells, to become "stress-primed" and malfunction. This state prevents them from clearing amyloid plaques, accelerating dementia risk. Now, using DARI seedling grants, Souza is testing a stem-cell-derived "EV therapy" designed to keep these cells healthy and prevent neuroinflammation.