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Summary: Genetically silencing mTORC2 in mouse models prolonged lifespan, suppressed seizures, increased long-term memory, and reduced autism-like behaviors.
Source: Baylor College of Medicine
Autism is a developmental disorder that affects 1 in 59 children in the U.S. Mutations in specific genes, such as PTEN, can explain many autism cases. While children with mutations in PTEN exhibit autism, microcephaly (an abnormally large skull), intellectual disability and epilepsy, there are currently no effective treatment options for children affected by this condition. But a new study by researchers at Baylor College of Medicine offers a potential new approach to therapy.
Published today in Nature Medicine, the study showed that a previously unexplored pathway goes awry in the brain of PTEN-deficient mice, and its restoration reverses their behavioral and neurophysiological abnormalities. More importantly, the researchers developed a new therapeutic strategy to treat the symptoms associated with PTEN-deficiency in this mouse model.
“PTEN is associated with the mTOR signaling pathway, which includes two distinct molecular complexes — mTORC1 and mTORC2 — each one regulating different cellular functions,” said first author Chien-Ju Chen, a graduate student in the lab of corresponding author Dr. Mauro Costa-Mattioli, professor of neuroscience and Cullen Foundation Endowed Chair at Baylor College of Medicine.
Based largely on experiments with the drug rapamycin, it was widely believed that dysregulation of mTORC1 is responsible for the condition. However, Costa-Mattioli and his colleagues suspected that this was not the entire story since mTORC2 activity was also dysregulated in individuals with mutations in PTEN.
The researchers worked with a model of this condition in which mice were genetically engineered to lack PTEN specifically in neurons, the nerve cells of the brain. PTEN-deficient mice present with macrocephaly, seizures, shorter lifespan, alterations in social behaviors as well as memory problems similar to those observed in patients with autism spectrum disorders.
The investigators used molecular genetics techniques to independently suppress mTORC1 and mTORC2 and determined how individual silencing of these complexes affected the neurological alterations. “The results were quite surprising because they went against the traditional view of the field,” said Costa-Mattioli, who also is director of the Memory and Brain Research Center at Baylor College of Medicine.
“We found that genetically silencing the mTORC1 complex in PTEN-deficiency mice only resulted in restoration of the size of the brain. It did not affect survival, the behavioral alterations or even the number seizures. Unexpectedly, genetically silencing mTORC2 complex activity resulted in prolonged lifespan, suppressed seizures, rescue of long-term memory and reduced autism spectrum disorder-like behaviors,” Costa-Mattioli said.
Currently, there is no drug that could specifically inhibit mTORC2. Thinking of possible future clinical applications of these findings, the researchers developed an antisense oligonucleotide, a molecule that silences the activity of mTORC2 by preventing the synthesis of one of its defining components.
“Amazingly, when we administered a single injection of the anti-sense oligonucleotide, we were able to reverse the abnormal behaviors and reduce seizures in Pten-deficient mice,” Chen said.
These findings are important because research efforts have mainly been focused on developing drugs to modulate mTORC1. Costa-Mattioli and his colleagues found that brain size and behavior are regulated by different mTOR complexes and molecular processes. More importantly, they found that mTORC2 is the major driver of the behavioral and other neurological alterations in PTEN-deficient mice, and their findings suggest that modulation of mTORC2 activity is a promising therapeutic approach.
“For other conditions, like spinal muscular atrophy, anti-sense oligonucleotides have successfully been translated into the clinic. This opens the possibility that either this or drug-based therapeutic modulation of mTORC2 activity also could be developed into a promising strategy to treat neurological disorders in which mTORC2 activity is dysregualted,” Costa-Mattioli said.
Finally, mTOR signaling also is altered in other neurological disorders, including epilepsy, tuberous sclerosis, Fragile X syndrome and Alzheimer disease. Future experiments should determine whether mTORC2 also is the main mTOR complex implicated in these disorders.
Other contributors to this work include Chien-Ju Chen, Martina Sgritta, Jacqunae Mays, Hongyi Zhou, Rocco Lucero, Jin Park, I-Ching Wang, Jun Hyoung Park, Benny Abraham Kaipparettu, Loredana Stoica, Paymaan Jafar-Nejad, Frank Rigo, Jeannie Chin and Jeffrey L. Noebels.
Funding: Financial support was provided by the following grants: NIMH 096816, Department of Defense AR120254, Sammons Enterprises, NINDS NS29709 and NS085171.
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Source: Baylor College of Medicine Media Contacts: Graciela Gutierrez – Baylor College of Medicine Image Source: The image is adapted from the Baylor College of Medicine news release.
Original Research: Closed access “Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency”. Chien-Ju Chen, Martina Sgritta, Jacqunae Mays, Hongyi Zhou, Rocco Lucero, Jin Park, I-Ching Wang, Jun Hyoung Park, Benny Abraham Kaipparettu, Loredana Stoica, Paymaan Jafar-Nejad, Frank Rigo, Jeannie Chin, Jeffrey L. Noebels & Mauro Costa-Mattioli. Nature Medicine doi:10.1038/s41591-019-0608-y.
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency
Dysregulation of the mammalian target of rapamycin (mTOR) signaling, which is mediated by two structurally and functionally distinct complexes, mTORC1 and mTORC2, has been implicated in several neurological disorders. Individuals carrying loss-of-function mutations in the phosphatase and tensin homolog (PTEN) gene, a negative regulator of mTOR signaling, are prone to developing macrocephaly, autism spectrum disorder (ASD), seizures and intellectual disability. It is generally believed that the neurological symptoms associated with loss of PTEN and other mTORopathies (for example, mutations in the tuberous sclerosis genes TSC1 or TSC2) are due to hyperactivation of mTORC1-mediated protein synthesis. Using molecular genetics, we unexpectedly found that genetic deletion of mTORC2 (but not mTORC1) activity prolonged lifespan, suppressed seizures, rescued ASD-like behaviors and long-term memory, and normalized metabolic changes in the brain of mice lacking Pten. In a more therapeutically oriented approach, we found that administration of an antisense oligonucleotide (ASO) targeting mTORC2’s defining component Rictor specifically inhibits mTORC2 activity and reverses the behavioral and neurophysiological abnormalities in adolescent Pten-deficient mice. Collectively, our findings indicate that mTORC2 is the major driver underlying the neuropathophysiology associated with Pten-deficiency, and its therapeutic reduction could represent a promising and broadly effective translational therapy for neurological disorders where mTOR signaling is dysregulated.
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