Genetically silencing mTORC2 in mouse models prolonged lifespan, suppressed seizures, increased long-term memory, and reduced autism-like behaviors.
NV-5138, a small molecule drug that mimics the action of ketamine, provides fast-acting antidepressant responses in rodent models of depression. The drug is currently undergoing Phase 1 testing in humans.
A new Neuron study reports blocking the action of the mTORC1 protein causes mice to stop problem drinking behaviors. The findings could help develop new treatments for addictive behaviors in people.
Researchers have identified a mechanism that allows the body to adapt to a low caloric intake and limits weight loss.
According to researchers, lithium, a drug commonly used to treat bipolar disorder, and rapamycin can help to protect neurons from further damage in those with TBI.
A new study reports sleep deprivation is tied to an impairment of protein production in the hippocampus.
A new study reports mitochondira are major triggers of cell aging.
A new study identifies a mechanism responsible for the degeneration of Purkinje cells in the cerebellum in Spinocerebellar ataxia type 1, a rare neurodegenerative disease.
According to a new study, the hormone Adiponectin can reverse the negative effects of obesity on offspring when infused into the placenta of obese, pregnant mice.
Researchers improve motor function and reduce brain shrinkage in animal models of HD by adjusting the levels of a signaling protein.
A new study points to a functional connection between mTOR and huntingtin.
The gene REDD1 enables stress to damage neurons and cause depressive behavior, a new study reports.
