Mutations of the PTEN gene cause neurons to grow to twice the size and form four times the number of synaptic connections to other neurons as a normal neuron. Removing the RAPTOR gene, an essential gene in the mTORC1 signaling pathway, prevents the neuronal and synaptic overgrowth associated with PTEN mutations. Using Rapamycin to inhibit mTORC1 recues all the changes in neuronal overgrowth.
NV-5138, a small molecule drug that mimics the action of ketamine, provides fast-acting antidepressant responses in rodent models of depression. The drug is currently undergoing Phase 1 testing in humans.
A new Neuron study reports blocking the action of the mTORC1 protein causes mice to stop problem drinking behaviors. The findings could help develop new treatments for addictive behaviors in people.
Researchers have identified a mechanism that allows the body to adapt to a low caloric intake and limits weight loss.
A new study reports sleep deprivation is tied to an impairment of protein production in the hippocampus.
A new study identifies a mechanism responsible for the degeneration of Purkinje cells in the cerebellum in Spinocerebellar ataxia type 1, a rare neurodegenerative disease.
Researchers improve motor function and reduce brain shrinkage in animal models of HD by adjusting the levels of a signaling protein.
A new study points to a functional connection between mTOR and huntingtin.