Researchers have identified a group of glucose-sensing neurons in the ventrolateral area of the ventromedial hypothalamic nucleus and discovered how they work together to prevent hypoglycemia in mice. Read More
Smoking remodels the gene expression of lung cells so that the ACE2 gene is more highly expressed in goblet cells. The effects of smoking on ACE2 pulmonary expression indicates an increase in the overall entry points for coronavirus and increases the risk for viral binding and entry of COVID-19 into the lungs. Read More
Administering medulloblastoma specific CAR T cells into the cerebrospinal fluid was more effective than administering via the blood. Read More
Mice deficient in the NFIA gene presented astrocytes with defective shapes and altered functions in the hippocampus. Read More
Study links olfactory perception to fat storage. Optogenetically inhibiting or activating an olfactory neural circuit in C. elegans promoted the loss or gain of fat storage. Read More
Several variants of the PIK3CA gene drive brain tumor progression. Two of the variants alter the expression of genes involved in synapses. Read More
Study finds no link between the abundance of herpes viral DNA or RNA and an increased risk of developing Alzheimer's disease. Read More
Genetically silencing mTORC2 in mouse models prolonged lifespan, suppressed seizures, increased long-term memory, and reduced autism-like behaviors. Read More
A new study identifies a novel neural network regulating feeding and mood in response to chronic stress. Inhibiting the POMC to ventral tegmental area circuit increases body weight and food intake while reducing depressive symptoms in mouse models. Read More
Islets of Langerhans in overnourished infant mice showed epigenetic profiles resembling those of much older mice. Read More
Study reveals how CD2AP may enhance Alzheimer's susceptibility. The gene affects neural communication by regulating the levels of regulatory proteins present around synapses. Read More
Seizures associated with Alzheimer's disease in both animal models and humans alter hippocampal neurogenesis. Treating mice with antiseizure medications normalized neurogenesis and improved spatial discrimination. Read More
