Mutations of the PTEN gene cause neurons to grow to twice the size and form four times the number of synaptic connections to other neurons as a normal neuron. Removing the RAPTOR gene, an essential gene in the mTORC1 signaling pathway, prevents the neuronal and synaptic overgrowth associated with PTEN mutations. Using Rapamycin to inhibit mTORC1 recues all the changes in neuronal overgrowth.
Brief exposure to Rapamycin, a promising anti-aging drug that has positive effects on health and lifespan, has the same effect as long-term exposure to the drug in animal models. The findings pave the way for testing the effects of short-term rapamycin exposure on the lifespan of humans.
Rapamycin, a drug approved for the treatment of cancer and transplant patients increases amyloid-beta protein plaques in the brains of mice.
Researchers propose a strategy for repurposing geroprotectors, including rapamycin and metformin, as potential COVID-19 infection prevention methods.
Study implicates disrupted autophagy and protein aggregation in the pathogenesis of autism schizophrenia and social behavior deficits in other disorders.
A new study reports the Ketogenic diet can help to improve cognition. The study reports the Ketogenic diet can help improve balance in the gut microbiome, lower blood glucose levels and increase the processes that help to clear amyloid beta from the brain.
Researchers are testing whether low doses of Rapamycin, a drug most commonly used as an immunosuppressant following an organ transplant, can help to prevent Alzheimer's disease.
A new Neuron study reports blocking the action of the mTORC1 protein causes mice to stop problem drinking behaviors. The findings could help develop new treatments for addictive behaviors in people.