rapamycin

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rapamycin

·December 8, 2022·3 min read

Anti-aging Drug Rapamycin Might Only Benefit Females

The anti-aging drug Rapamycin only prolongs the lifespan of females according to research using fruit fly and mouse models. Rapamycin increased autophagy in female intestinal cells, but not in males. Findings suggest biological sex may be a crucial factor in the effectiveness of anti-aging drugs.

Autism Featured Neuroscience

·November 1, 2022·4 min read

Study Offers New Insights Into Genetic Mutations in Autism Disorders and Points to Possible Treatments

Mutations of the PTEN gene cause neurons to grow to twice the size and form four times the number of synaptic connections to other neurons as a normal neuron. Removing the RAPTOR gene, an essential gene in the mTORC1 signaling pathway, prevents the neuronal and synaptic overgrowth associated with PTEN mutations. Using Rapamycin to inhibit mTORC1 recues all the changes in neuronal overgrowth.

This shows a person holding up a bottle of rapamycin

Featured Neuroscience

·August 29, 2022·4 min read

Brief Exposure to Rapamycin Has the Same Anti-aging Effects as Lifelong Treatment

Brief exposure to Rapamycin, a promising anti-aging drug that has positive effects on health and lifespan, has the same effect as long-term exposure to the drug in animal models. The findings pave the way for testing the effects of short-term rapamycin exposure on the lifespan of humans.

Featured Neurology Neuroscience

·June 7, 2022·3 min read

Rapamycin Increases Alzheimer’s-Associated Plaques in Mice

Rapamycin, a drug approved for the treatment of cancer and transplant patients increases amyloid-beta protein plaques in the brains of mice.

Featured Neuroscience Open Neuroscience Articles

·April 6, 2020·4 min read

Clinical trials of low-dose rapamycin to protect elderly from COVID-19 proposed

Researchers propose a strategy for repurposing geroprotectors, including rapamycin and metformin, as potential COVID-19 infection prevention methods.

Autism Featured Genetics Neuroscience

·October 21, 2019·4 min read

New therapeutic strategy may help reverse autism behavioral abnormalities

Genetically silencing mTORC2 in mouse models prolonged lifespan, suppressed seizures, increased long-term memory, and reduced autism-like behaviors.

Featured Genetics Neuroscience

·August 26, 2019·3 min read

Scientists have found longevity biomarkers

Exploring the effects of 17 different lifespan-extending interventions on gene activity, researchers identified genetic biomarkers for longevity in mice.

Featured Genetics Neuroscience Open Neuroscience Articles

·May 23, 2019·3 min read

A new pathway for an anti-aging drug

TRPML1 may contribute to the neuroprotective and anti-aging properties of rapamycin.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·April 10, 2019·4 min read

Protein pileup affects social behaviors through altered brain signaling

Study implicates disrupted autophagy and protein aggregation in the pathogenesis of autism schizophrenia and social behavior deficits in other disorders.

Featured Neuroscience Open Neuroscience Articles Psychology

·October 3, 2018·5 min read

Connection Between Cognitive Function and Diet

A new study reports the Ketogenic diet can help to improve cognition. The study reports the Ketogenic diet can help improve balance in the gut microbiome, lower blood glucose levels and increase the processes that help to clear amyloid beta from the brain.

Featured Neurology Neuroscience Videos

·October 6, 2017·2 min read

Researchers Studying Drug’s Potential to Prevent Alzheimer’s

Researchers are testing whether low doses of Rapamycin, a drug most commonly used as an immunosuppressant following an organ transplant, can help to prevent Alzheimer's disease.

Featured Neuroscience Psychology

·September 11, 2017·5 min read

Protein Links Alcohol Abuse and Changes in Brain’s Reward Center

A new Neuron study reports blocking the action of the mTORC1 protein causes mice to stop problem drinking behaviors. The findings could help develop new treatments for addictive behaviors in people.

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