Anticoagulant drugs that inhibit thrombin were shown to reduce the number of brain metastases in mouse models. Read More
A series of ketamine infusions reduced PTSD symptoms by up to 30% from baseline compared to treatment with midazolam, which reduced symptoms by 20% over the same period. Ketamine treatment significantly reduced three of four PTSD associated symptoms, including intrusive thoughts, avoidance, and negative alterations in cognition and mood. Read More
As with other psychedelics, salvinorin A increased activity across the brain. However, salvinorin A use resulted in more random and disconnected signaling in the default mode network, a brain network associated with relaxing and daydreaming. Read More
A new nanoparticle drug-delivery system resulted in unprecedented siRNA penetration across the intact blood-brain barrier. Researchers say the system could help doctors to treat secondary injuries associated with TBI that can result in Alzheimer's and other neurodegenerative disorders. Read More
Treatment with LAU-0901, a synthetic molecule that blocks pro-inflammatory platelet-activating factor, in addition to aspirin-triggered NPD1, reduced the size of damage areas in the brain, initiated repair mechanisms, and improved behavioral recovery following ischemic stroke. Read More
A single dose of psychedelic treatments can help alleviate symptoms of depression, stress, and trauma in those who have experienced racial injustice. Read More
Loperamide, an anti-diarrhea medication, induces autophagy in glioblastoma brain cancer cells. Read More
4E-BPs proteins are key to unlocking ketamine's antidepressant effects. When 4E-BPs are absent in neurons, ketamine can not produce its antidepressant effect. Read More
Ezogabine, an antiepileptic drug, reduces the excitability of cortical and spinal motor neurons associated with ALS. Read More
Genetically modified tomatoes enriched with L-DOPA may become a new and more affordable source for the essential Parkinson's disease drug. Read More
Researchers have developed a non-hallucinogenic version of the drug ibogaine which has the potential to treat depression, addiction, anxiety, and a range of other mental health disorders. Read More
Researchers have identified a biochemical cascade that leads to the destruction of synapses in the brain. The findings open new avenues of research into the treatment of Alzheimer's disease. Read More
