Compounds based on CBD can reduce fentanyl opioid binding and boost the effects of naloxone, a fast-acting opioid antidote.
Researchers have developed a new molecule that limits magnesium transport in mitochondria. The drug prevents weight gain and liver damage in mice who were fed a high-sugar, Western-style diet since birth. After exposure to the molecule, overweight mice started to lose weight.
Exenatide, an injectable peptide currently in phase two clinical trials for treating type 2 diabetes, reduces symptoms of Idiopathic Intercranial Hypertension blinding headaches, a new study reports.
Solanezumab, an investigational anti-amyloid treatment, does not significantly slow the cognitive decline associated with Alzheimer's disease.
A small group of neurons in the airway plays a key role in altering the brain of the presence of flu infection in the body, and a second pathway from the lungs to the brain becomes active later in infection. The findings also shed light on how NSAID anti-inflammatory medications alleviate flu symptoms.
In recent research, scientists have discovered that blood vessels feeding high-grade glioma brain tumors have high levels of LDL receptors (LDLR) on them. The study found that using drug-containing nanoparticle-based therapies to target these receptors can be a new way of treating cancer. Gliomas are the most common primary brain tumors and, due to their highly aggressive nature, have a poor prognosis with an average survival of only 4.6 months without treatment and approximately 14 months with optimal multimodal treatments. This research could pave the way for treating glioma brain tumors with LDL receptor-targeted nanoparticle-based therapies, thereby cutting off the energy supply of cancer cells.
Using AI, researchers identified Probucol, an existing anti-cholesterol drug that promotes the disposal of mitochondria, as a potential new therapy for the treatment of Parkinson's disease.
Researchers have developed a compound that can target and break down a post-transitionally modified protein associated with Alzheimer's disease.
Microglia appear to be associated with brain fog and memory problems that arise as a result of exposure to chemotherapy, researchers discovered. Deleting the immune cells from the microglia in mice who received the chemotherapy drug paclitaxel lowered inflammation and restored memory function.
Artificial intelligence was able to determine different behavioral phenotypes at different stages in the development of epilepsy in mice.
Prazosin, an FDA-approved medication for the treatment of hypertension may help to prevent relapse in people with cardiovascular and behavioral symptoms of alcohol withdrawal, a new study reports.
Fentanyl enhances direct pathway medium spiny neurons activity in the striatum. During withdrawal from the opioid, inhibitory signals from direct pathway medium spiny neurons to dopaminergic neurons become enhanced. The enhanced suppression of dopaminergic neurons contributes to the negative emotions associated with fentanyl withdrawal. Inhibiting the direct pathway medium spiny neurons can reduce withdrawal symptoms and associated anxiety behaviors.
