Summary: Consuming too much omega 6 during pregnancy has been linked to an increased risk of neurodevelopmental issues in babies and pregnancy complications. In mice who had higher levels of linoleic acid in their diets, researchers noted altered concentrations of inflammatory proteins and a decrease in hormones that regulate fetal growth and development. Researchers stress the effects of a high linoleic acid concentration in diet are the same for both animal models and humans.
Source: The Physiological Society
In Western societies, we are eating more omega 6 fats, particularly linoleic acid, which are present in foods such as potato chips and vegetable oil. Other research has shown that linoleic acid can promote inflammation and may be associated with an increased risk of heart disease.
New research in The Journal of Physiology showed that eating a diet with three times the recommended daily intake of linoleic acid might be harmful in pregnancy. They found three changes in rat mothers who ate a high linoleic acid diet: their liver had altered concentrations of inflammatory proteins, their circulating concentrations of a protein that can cause contraction of the uterus during pregnancy were increased, and a hormone that can regulate growth and development was decreased. These changes may result in an increased risk of pregnancy complications and poor development of the babies.
If the effects of high linoleic acid are the same in rats and humans, this would suggest that women of child-bearing age should consider reducing the amount of linoleic acid in their diet.
The researchers fed rats for 10 weeks on a diet with high linoleic acid, mated them and then investigated the effects of the diet on their pregnancy and developing babies. They specifically investigated any changes in the body and organ weights of the mothers and her babies, and concentrations of circulating and liver inflammatory proteins, cholesterol, and the hormone leptin. Rats typically give birth to multiple babies in each pregnancy. Rat mothers who ate a high linoleic acid diet had a reduced number of male babies.
It is important to note that when humans eat a diet rich in linoleic acid, the diet also tends to be high in fat, sugar and salt. However, in the study, the only change in the diet was higher linoleic acid, but no changes in fat, sugar or salt.
Deanne Skelly, the senior author on the paper, said:
“It is important for pregnant women to consider their diet, and our research is yet another example that potentially consuming too much of a certain type of nutrient can have a negative impact on the growing baby.”
About this neuroscience research article
Source: The Physiological Society Media Contacts: Julia Turan – The Physiological Society Image Source: The image is in the public domain.
Original Research: The study will appear in The Journal of Physiology.