Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.
Cholesterol produced by astrocytes in the brain is required for the production of amyloid-beta. The findings shed light on how and why amyloid-beta forms, and may explain why genes associated with cholesterol have been implicated as risk factors for Alzheimer's disease.
A study conducted on Japanese men and women found peanut consumption decreased the risk of cardiovascular disease and ischemic stroke.
Lower cholesterol levels may put people with schizophrenia at higher risk for violent behaviors, including self-harm and suicide. Researchers say lower cholesterol levels make brain cells less sensitive to serotonin, increasing symptoms of depression, impulsivity, and aggression.
High blood pressure, obesity, higher levels of cholesterol, and high blood sugar levels experienced by people in their 20s and 30s appear to have a negative impact on cognitive skills later in life.
Study reveals a link between cholesterol metabolism and a subtype of autism. The association appears to have a genetic component. Mothers with lipid abnormalities are 16% more likely to have a child diagnosed with ASD, and fathers with abnormal lipid levels were 14% more likely. Individuals on the autism spectrum were twice as likely to have lipid abnormalities than those without ASD. Among those with ASD and abnormal lipid levels, conditions such as ASD, epilepsy, and sleep disorders were more common than in those with normal levels. Findings suggest dyslipidemia may alter neurodevelopment and result in other medical conditions, such as anemia and vitamin D deficiency.
Study in rats reveals sex differences may play a key role in the effectiveness of exercise as an appetite regulator. Exercising female rats ate more than those who did not partake in physical activity. The same effect was not seen in males.
Children born with high levels of triglycerides and low-density lipoprotein in their cord blood samples were more likely to receive lower ratings from their teachers on both social and emotional development scales.