Researchers report mice can retain their memories and ability to learn when almost all ApoE is removed from the brain but kept present in the liver to filter cholesterol.
FIASMA antidepressants, such as amitriptyline and desipramine, halt the growth of four different kinds of bacterial pathogens in cell cultures and animal models. The antidepressants have shown to be effective in killing intracellular bacteria in two chlamydia infections, as well as human granulocytic anaplasmosis, a tick-borne disease that attacks white blood cells.
Study reveals a link between cholesterol metabolism and a subtype of autism. The association appears to have a genetic component. Mothers with lipid abnormalities are 16% more likely to have a child diagnosed with ASD, and fathers with abnormal lipid levels were 14% more likely. Individuals on the autism spectrum were twice as likely to have lipid abnormalities than those without ASD. Among those with ASD and abnormal lipid levels, conditions such as ASD, epilepsy, and sleep disorders were more common than in those with normal levels. Findings suggest dyslipidemia may alter neurodevelopment and result in other medical conditions, such as anemia and vitamin D deficiency.
Study reports oligodendrocytes in the brain are distinct from oligodendrocytes in the central nervous system due to their metabolic processes. The findings may shed new light on neurological and autoimmune dysfunction in multiple sclerosis and other neurodegenerative disorders.
University of Cambridge researchers report cholesterol may play a role in the onset of Alzheimer's disease. Researchers discovered cholesterol can trigger amyloid beta to aggregate, which can lead to neuron death.
Children born with high levels of triglycerides and low-density lipoprotein in their cord blood samples were more likely to receive lower ratings from their teachers on both social and emotional development scales.
Cyclodextrin, an FDA-approved drug, reduced cholesterol accumulation from broken down brain cells and inflammation in animal models. The findings point to a potential new therapy to reduce dementia following a stroke.
Cholesterol produced by astrocytes in the brain is required for the production of amyloid-beta. The findings shed light on how and why amyloid-beta forms, and may explain why genes associated with cholesterol have been implicated as risk factors for Alzheimer's disease.