FeaturedGeneticsNeurology·June 23, 2020·5 min readNew gene may drive earliest brain changes in Alzheimer’sGenetic analysis of almost 4,300 samples reveals a link between the appearance of amyloid deposits, APOE, and a novel gene called RBFOX1. Lower levels of RBFOX1 in the brain appear to be associated with increased amyloid and global cognitive decline over a person's lifetime.Read More
FeaturedNeurologyNeuroscience·June 15, 2020·4 min readNew indication of a link between Alzheimer’s and diabetesA new high-resolution 3D model reveals strong similarities in fibril structures associated with Alzheimer's and type 2 diabetes.Read More
FeaturedNeurologyNeuroscience·June 9, 2020·4 min readNoise-inducing neurons shut down memories in Alzheimer’sIn mouse models of Alzheimer's disease, active neurons still encode memory, and a group of active neurons encodes novel environmental information. The signal of the novelty containing neurons causes a superimposition disturbing the signal of memory encoding neurons.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience ArticlesPsychology·June 8, 2020·5 min readRepetitive negative thinking linked to dementia riskRepetitive negative thinking (RNT) in those aged over 55 is associated with an increased risk of cognitive decline and deposition of proteins associated with Alzheimer's disease. People who exhibited higher levels of RNT experienced more cognitive and memory problems over four years. They were more likely to have both amyloid-beta and tau protein deposits throughout the brain.Read More
FeaturedNeuroscience·June 5, 2020·2 min readEarly-life education improves memory in old age, especially for womenFemales who attend school for longer have better memory ability in old age, a new study reports. For each year of education, memory gains were, on average, five times greater for women than the losses experienced due to each year of aging.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·May 30, 2020·3 min readNew gut-brain link: How gut mucus could help treat brain disordersChanges in gut mucus may contribute to Alzheimer's, Parkinson's, and other neurological disorders. Researchers noted changes in types of gut mucus bacteria in those with a range of neurological disorders compared to their healthy peers. Findings suggest those with reduced gut mucus protection may be more susceptible to gastrointestinal problems.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·May 29, 2020·2 min readHow toxic protein spreads in Alzheimer’s diseaseTau spreads through the human brain via neural communication pathways. The spread is accelerated by the presence of amyloid-beta.Read More
FeaturedGeneticsNeuroscienceOpen Neuroscience Articles·May 26, 2020·3 min readDementia gene raises risk of severe COVID-19People with the Alzheimer's associated ApoE e4e4 gene have increased vulnerability to developing severe symptoms of COVID-19 if they become infected with the virus. Findings suggest those with the dementia-related gene have double the risk of developing severe coronavirus symptoms compared to those who those with the common e3e3 form of the APOE gene.Read More
FeaturedNeurologyNeuroscience·May 21, 2020·4 min readExercise improves memory and boosts blood flow to brainFollowing a one year program of aerobic exercise improves memory function and boosts blood flow to brain areas critical for cognition in older adults with risk factors for dementia.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·May 16, 2020·4 min readCertain Memory Complaints Predict Future DementiaSubjective cognitive complaints may be the earliest detectable stages of preclinical dementia.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·May 14, 2020·4 min readRetinal texture could provide early biomarker of Alzheimer’s diseaseThe topmost layer of neurons in the retina of mouse models of Alzheimer's disease exhibits textural changes. The findings could be a new biomarker for Alzheimer's disease.Read More
FeaturedNeurologyNeuroscience·May 11, 2020·4 min read3D brain-like tissue model links Alzheimer’s disease with herpesA 3D human tissue culture model demonstrated a possible causal relationship between Alzheimer's disease and herpes simplex virus 1 (HSV-1) infection. 40 Alzheimer's associated genes were over-expressed in the HSV-1 infected brain tissue, including genes associated with the production of amyloid-beta.Read More
