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alpha-synuclein

Featured Neurology Neuroscience Open Neuroscience Articles

·November 14, 2019·4 min read

Targeting alpha-synuclein in the gut may slow down Parkinson’s disease

Scientists are conducting experiments to see if targeting the enteric nervous system with a compound can inhibit the aggregation of alpha-synuclein and slow the progression of Parkinson's disease.

This shows the outline of two bodies. One has the head highlighted red, the other has the gut highlighted red

Featured Neurology Neuroscience Open Neuroscience Articles

·November 7, 2019·4 min read

Where does Parkinson’s disease start? In the brain or gut? Or both?

Lewy body disorders, including Parkinson's disease and Lewy body dementia, comprise of two distinct subtypes. One subtype originates in the peripheral nervous system (PNS) of the gut and spreads to the brain. The other originates in the brain, or enters the brain via the olfactory system, before spreading to the brainstem and PNS.

Featured Neurology Neuroscience

·October 3, 2019·5 min read

Parkinson’s disease is also present in the blood

Parkinson's disease involves monocytic alterations in the blood. The cells have reduced viability and are unresponsive to specific stimuli, which could have relevant consequences for the progression of Parkinson's. Immune modulation medications may be a new treatment option to inhibit neurodegeneration associated with PD.

Featured Neurology Neuroscience Open Neuroscience Articles

·September 3, 2019·4 min read

Parkinson’s disease may originate in the intestines

Two months after injecting alpha-synuclein into the intestines of rats, researchers discovered the proteins had traveled to the brain via peripheral nerves. Four months later, the pathology was greater. Additionally, the protein had traveled to the heart. The study supports the hypothesis that Parkinson's disease may begin in the intestinal system before migrating to the brain.

Featured Neurology Neuroscience

·August 12, 2019·3 min read

Estrogen improves Parkinson’s disease symptoms

Selective estrogen treatments appear to reduce symptoms of Parkinson's disease in male mice. The study sheds light on sex-based differences associated with the disease and may provide new therapeutic avenues for treatment.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·July 29, 2019·4 min read

Discovery could lead to new treatments for Parkinson’s, other brain diseases

New model could inform the development of new treatments for Lewy body diseases by targeting alpha-synuclein DNA repair mechanisms.

This diagram shows how a-synuclein travels from the gut to the brain via the vagus nerve

Featured Neurology Neuroscience Neuroscience Videos Open Neuroscience Articles

·June 26, 2019·6 min read

New research shows Parkinson’s disease origins in the gut

A new study adds to the growing body of evidence that Parkinson's disease may start in the gut. Researchers found gut-to-brain propagation of alpha-synuclein spread via the vagus nerve. The study provides a more accurate model of Parkinson's progression and could lead to new treatments to halt or prevent this neurodegenerative disease.

This shows PET scans of a Parkinsons brain

Featured Genetics Neurology Neuroscience

·June 20, 2019·6 min read

Study reveals roots of Parkinson’s in the brain

Changes in the brain's serotonin system may occur years before Parkinson's disease symptoms begin. Serotonin alterations could be used as a biomarker for Parkinson's disease.

Featured Neurology Neuroscience

·May 10, 2019·4 min read

Inflamed monkey guts produce Parkinson’s-related proteins

Inflammation of the colon is associated with alterations in alpha-synuclein expression and phosphorylation in the myenteric plexus of common marmoset monkeys. The findings support the growing body of evidence that inflammation may play a role in the development of Parkinson's disease.

Featured Neurology Open Neuroscience Articles

·March 13, 2019·4 min read

Researchers Explore Link Between Metal Exposure and Parkinson’s Symptoms

Chronic exposure to manganese, as experienced by some working as industrial welders, has been linked to the onset of Parkinson's like symptoms. Researchers report manganese exposure can cause misfolded alpha-synuclein, a hallmark of Parkinson's disease.

Featured Neurology Open Neuroscience Articles

·February 7, 2019·4 min read

The Gut’s Link to Parkinson’s: Hype or Hope?

Researchers review the evidence that Parkinson's disease may, at least for some patients, begin in the gut.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 10, 2019·4 min read

Defective Glial Cells Can Push Neurons Toward Parkinson’s Disease

A new study reveals a defective version of astrocytes may be linked to the build up of alpha synuclein and could spur Parkinson's disease. The findings show the important role glial cells play in Parkinson's and offers insights into new targets for therapies to fight the neurodegenerative disease.

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alpha-synuclein

Targeting alpha-synuclein in the gut may slow down Parkinson’s disease

Where does Parkinson’s disease start? In the brain or gut? Or both?

Parkinson’s disease is also present in the blood

Parkinson’s disease may originate in the intestines

Estrogen improves Parkinson’s disease symptoms

Discovery could lead to new treatments for Parkinson’s, other brain diseases

New research shows Parkinson’s disease origins in the gut

Study reveals roots of Parkinson’s in the brain

Inflamed monkey guts produce Parkinson’s-related proteins

Researchers Explore Link Between Metal Exposure and Parkinson’s Symptoms

The Gut’s Link to Parkinson’s: Hype or Hope?

Defective Glial Cells Can Push Neurons Toward Parkinson’s Disease

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