The Parkinson's-associated protein alpha-synuclein appears to act as a "toggle switch" that helps control vesicle transportation and gene expression. In a diseased state, this delicate balance is broken. The findings have implications for the development of new treatments for Parkinson's disease.
A Nature Neuroscience study reveals the normal role of alpha-synuclein, a protein implicated in Parkinson's disease. Researchers say understanding how the protein normally acts may give insights into how it might fail.