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alpha-synuclein

·June 20, 2011·2 min read

USC Researchers Find New Clues About Protein Linked To Parkinson’s Disease

Structural biologists at the Keck School of Medicine of USC are the first to measure the energy difference between protein...

Genetics

·February 7, 2012·2 min read

Researchers Increase Understanding of Gene’s Potentially Protective Role in Parkinson’s

Treatments for Parkinson’s disease, estimated to affect 1 million Americans, have yet to prove effective in slowing the progression of...

Featured Neurology Open Neuroscience Articles

·June 27, 2012·4 min read

Finding Brings Scientists One Step Closer to Parkinson’s Drug

Long-term aim is to develop new treatments to block the spread of damaged proteins in the brain. Van Andel Institute...

Electrophysiology Featured Genetics Neurology

·July 18, 2012·2 min read

Protein Build-Up Leads to Neurons Misfiring

Using a two-photon microscope capable of peering deep within living tissue, researchers at the University of California, San Diego School of Medicine have found new evidence that alpha-synuclein protein build-up inside neurons causes them to not only become leaky, but also to misfire due to calcium fluxes.

Image shows brain slices with deposits of proteins associated with Alzheimer's and Parkinson's disease.

Featured Neurology

·February 5, 2013·3 min read

Study Confirms No Transmission of Alzheimer’s Proteins Between Humans

While evidence suggests pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals, new research shows no evidence to support concerns that these abnormal disease proteins are “infectious” or transmitted from animals to humans or from one person to another.

The image shows an over-sized terminal forms a synapse with a dendritic spine. The caption best describes the image.

Featured Neurology

·February 7, 2013·3 min read

Excess Protein Linked to Development of Parkinson’s Disease

Researchers suggest the overexpression of a protein called alpha-synuclein appears to disrupt vital recycling processes in neurons. The study may have major implications for more fully understanding the causes and mechanisms of Parkinson’s disease.

The image shows the structure of the LRRK2 protein.

Featured Genetics

·March 5, 2013·3 min read

Improper Protein Degradation in Neurons Identified as a Cause of Familial Parkinson’s

Studying neurons derived from brain and skin cells of Parkinson's patients, researchers discover how the most common genetic mutations in familial Parkinson's disease damage brain cells.

Three panels show tangles and Lewy bodies.

Featured Neurology

·July 3, 2013·4 min read

Shape-shifting Disease Proteins May Explain Variable Appearance of Neurodegenerative Diseases

Researchers discover alpha-synuclein proteins can morph into different strains. This can promote misfolding of other disease proteins associated with neurodegenerative diseases.

This is an immunohistochemistry image showing alpha-synuclein positive staining.

Featured Neurology

·October 7, 2013·3 min read

Study Identifies Possible Biomarker for Parkinson’s Disease

Researchers report of elevated alpha-synuclein levels detected on the skin of patients with Parkinson's disease. The findings could offer a new biomarker for the recognition of Parkinson's before the disease reaches advanced stage.

The iamge shows the spaghetti type polymer. The caption best describes the image.

Featured Neurology Open Neuroscience Articles

·October 13, 2013·3 min read

Two Forms of Parkinson’s Disease Identified

Researchers have succeeded in characterizing and producing two different types of alpha-synuclein aggregates. One of which is more toxic and has greater capacity to invade neurons.

The image shows the dual yeast and stem cell platform. The caption best describes the image.

Featured Neurology

·October 24, 2013·5 min read

Yeast, Human Stem Cells Drive Discovery of New Parkinson’s Disease Drug Targets

Researchers have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson’s patients.

The slides shown are taken from the research, The caption best explains the image.

Featured Neurology Open Neuroscience Articles

·October 30, 2013·2 min read

Absence of the SMG1 Protein Could Contribute to Parkinson’s and Other Neurological Disorders

A new study links a lack of SMG1 to protein aggregates associated with Parkinson's disease and other neurodegenerative diseases.

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alpha-synuclein

USC Researchers Find New Clues About Protein Linked To Parkinson’s Disease

Researchers Increase Understanding of Gene’s Potentially Protective Role in Parkinson’s

Finding Brings Scientists One Step Closer to Parkinson’s Drug

Protein Build-Up Leads to Neurons Misfiring

Study Confirms No Transmission of Alzheimer’s Proteins Between Humans

Excess Protein Linked to Development of Parkinson’s Disease

Improper Protein Degradation in Neurons Identified as a Cause of Familial Parkinson’s

Shape-shifting Disease Proteins May Explain Variable Appearance of Neurodegenerative Diseases

Study Identifies Possible Biomarker for Parkinson’s Disease

Two Forms of Parkinson’s Disease Identified

Yeast, Human Stem Cells Drive Discovery of New Parkinson’s Disease Drug Targets

Absence of the SMG1 Protein Could Contribute to Parkinson’s and Other Neurological Disorders

Untangling the Human Mind: The Interplay Between Cognition and Personality

Empathy’s Influence on Drinking Patterns

Sleep Apnea and Its Link to Alzheimer’s Associated Brain Changes

Getting the Skinny on Cannabis Use: The Effect of Cannabis on Weight and Metabolism

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