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alpha-synuclein

·April 28, 2021·7 min read

New Model May Explain the Mystery of Asymmetry in Parkinson’s Disease

A new model of Parkinson's disease sheds light on the asymmetrical motor symptoms, and other disorders, associated with this disease.

This is a computerized representation of a neuron

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·February 10, 2021·4 min read

Function Identified of ‘Mystery Protein’ That Kills Brain Cells of People With Parkinson’s

Study sheds new light on the damage alpha-synuclein does to neurons in Parkison's disease patients.

Featured Genetics Neurology Open Neuroscience Articles

·August 23, 2020·4 min read

Unique Protein Structures Could Hold the Key to Parkinson’s Disease

Researchers have discovered a series of misfolded alpha-synuclein protein structures never previously observed. The alpha-synuclein fibers were larger than previously reported and adopted a striking variety of shapes. The work lays the foundation for a detailed analysis of misfolded alpha-synuclein structures and could provide a better understanding of the neurobiology of Parkinson's disease.

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·April 30, 2020·3 min read

Researchers unravel protein mystery of three brain diseases

Researchers have identified two different shapes of alpha-synuclein associated with multiple systems atrophy (MSA) and Lewy body dementia. The structure of the protein is helical in MSA, causing the symptoms to occur more quickly and aggressively. In Lewy body dementia, the protein takes on a cylindrical form.

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·April 20, 2020·4 min read

Further evidence autoimmunity plays a role in Parkinson’s disease

T cells that react to alpha-synuclein are most abundant in the early stages of Parkinson's disease but tend to disappear as the disease progresses. Signs of autoimmunity can appear in Parkinson's patients up to ten years before a diagnosis of the neurodegenerative disease. The detection of T cell response could be an early biomarker for Parkinson's, long before the physical symptoms begin to manifest.

Featured Neurology Neuroscience

·March 13, 2020·5 min read

‘Natural killer’ cells could halt Parkinson’s progression

Natural killer cells may play a critical role in regulating and restraining neuroinflammation and protein clumping associated with Parkinson's disease.

Featured Neurology Neuroscience

·March 11, 2020·5 min read

New target for Parkinson’s therapies identified

Two regions outside of the non-amyloid-beta-component play a critical role in controlling amyloid formation of alpha-synuclein.

Featured Neurology Neuroscience

·February 18, 2020·5 min read

Parkinson’s biomarker may originate in gut

Using mouse models, researchers seeded alpha-synuclein aggregates in gut neurons and discovered the clumps can travel to neurons in the brain.

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·February 16, 2020·4 min read

Cough syrup drug being trialed as Parkinson’s treatment

Ambroxol, a medication approved to treat coughs, may slow the progression of Parkinson's disease. The medication is able to effectively cross the blood-brain barrier and increases levels of GCase in patients' brains. Ambroxol also appears to reduce Parkinson's-related alpha-synuclein levels.

Featured Genetics Neurology Neuroscience

·January 27, 2020·5 min read

Parkinson’s disease may start before birth

10% of patients diagnosed with Parkinson's disease are between the ages of 21 and 50. For those with young-onset Parkinson's disease, researchers report the foundations for the disease may have been apparent before they were born. The study also points to a drug, currently approved to treat precancerous skin growths, that has the potential to reduce elevated levels of alpha-synuclein.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·January 17, 2020·3 min read

New insights into a Parkinson’s disease protein

Alpha synuclein's non-amyloidal component (NAC) aids the protein's movement through axons. When the NAC region is removed, alpha-synuclein did not move within axons.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 14, 2020·3 min read

Probiotic could guard against Parkinson’s

Building on previous research that links gut bacteria to the development of Parkinson's disease, researchers identified a probiotic which prevents the formation of alpha-synuclein.

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alpha-synuclein

New Model May Explain the Mystery of Asymmetry in Parkinson’s Disease

Function Identified of ‘Mystery Protein’ That Kills Brain Cells of People With Parkinson’s

Unique Protein Structures Could Hold the Key to Parkinson’s Disease

Researchers unravel protein mystery of three brain diseases

Further evidence autoimmunity plays a role in Parkinson’s disease

‘Natural killer’ cells could halt Parkinson’s progression

New target for Parkinson’s therapies identified

Parkinson’s biomarker may originate in gut

Cough syrup drug being trialed as Parkinson’s treatment

Parkinson’s disease may start before birth

New insights into a Parkinson’s disease protein

Probiotic could guard against Parkinson’s

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