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alpha-synuclein

·August 21, 2015·5 min read

Break in Working Relationship Between Two Trash Clearing Proteins May Result in Parkinson’s Disease

According to a new study, when two debris clearing proteins don't work together as they should, Parkinson's disease can occur.

Featured Neurology Neuroscience Open Neuroscience Articles

·February 16, 2020·4 min read

Cough syrup drug being trialed as Parkinson’s treatment

Ambroxol, a medication approved to treat coughs, may slow the progression of Parkinson's disease. The medication is able to effectively cross the blood-brain barrier and increases levels of GCase in patients' brains. Ambroxol also appears to reduce Parkinson's-related alpha-synuclein levels.

Featured Genetics Neurology Neuroscience

·February 2, 2022·4 min read

New Non-Mutated Protein Linked to Dementia

APOE proteins were enhanced in the brains of patients with dementia, even when they did not carry the Alzheimer's associated gene.

Image shows a doctor looking at brain scans.

Featured Neurology

·July 9, 2017·5 min read

What’s the Difference Between Alzheimer’s Disease and Dementia?

A common misconception is that Alzheimer's disease and dementia are the same thing. Alzheimer's disease is simply one form of dementia. Researchers from Texas A&M describe how Alzheimer's and other forms of dementia impact the lives of both patients and their families, and provide new insights into minimizing the risks of developing neurodegenerative conditions.

Image shows brain slices with deposits of proteins associated with Alzheimer's and Parkinson's disease.

Featured Neurology

·February 5, 2013·3 min read

Study Confirms No Transmission of Alzheimer’s Proteins Between Humans

While evidence suggests pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals, new research shows no evidence to support concerns that these abnormal disease proteins are “infectious” or transmitted from animals to humans or from one person to another.

Neuroscience

·June 20, 2011·2 min read

USC Researchers Find New Clues About Protein Linked To Parkinson’s Disease

Structural biologists at the Keck School of Medicine of USC are the first to measure the energy difference between protein...

Featured Neurology Open Neuroscience Articles

·December 20, 2017·4 min read

Findings Point to Potential New Therapy for Parkinson’s

A new PNAS study reveals an FDA approved drug that targets toxic protein interactions could be used as a novel treatment for Parkinson's disease.

Featured Neurology Open Neuroscience Articles

·April 6, 2018·4 min read

New Blood Test Useful to Detect Those at Risk of Developing Alzheimer’s

Researchers have developed a new blood test capable of detecting biomarkers of Alzheimer's disease long before the first symptoms appear.

This shows the outline of two bodies. One has the head highlighted red, the other has the gut highlighted red

Featured Neurology Neuroscience Open Neuroscience Articles

·November 7, 2019·4 min read

Where does Parkinson’s disease start? In the brain or gut? Or both?

Lewy body disorders, including Parkinson's disease and Lewy body dementia, comprise of two distinct subtypes. One subtype originates in the peripheral nervous system (PNS) of the gut and spreads to the brain. The other originates in the brain, or enters the brain via the olfactory system, before spreading to the brainstem and PNS.

Featured Genetics Open Neuroscience Articles

·February 18, 2016·4 min read

Stem Cell Study Reveals How Parkinson’s Spreads

A new stem cell study offers clues as to how Parkinson's disease spreads from cell to cell.

Electrophysiology Featured Genetics Neurology

·July 18, 2012·2 min read

Protein Build-Up Leads to Neurons Misfiring

Using a two-photon microscope capable of peering deep within living tissue, researchers at the University of California, San Diego School of Medicine have found new evidence that alpha-synuclein protein build-up inside neurons causes them to not only become leaky, but also to misfire due to calcium fluxes.