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neurogenesis

·August 29, 2019·6 min read

Machine learning algorithm can’t distinguish these lab mini-brains from preemie babies

Machine learning is unable to tell the difference in brain activity between a lab-grown mini-brain and that of a preterm infant who has reached full-term.

This shows Id4 expression in hippocampal neurons

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·August 29, 2019·3 min read

Signal blocks stem cell division in the geriatric brain

A gene regulated called Id4 appears to be a key component in controlling stem cell proliferation.

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·August 20, 2019·4 min read

Alzheimer’s drug reverses brain damage from adolescent alcohol exposure

Donepezil, a drug routinely administered to slow cognitive decline in Alzheimer's disease, shows promise in treating damage caused to the brain by adolescent alcohol exposure. The drug reverses neuroinflammation and neuron damage in rats exposed to alcohol during adolescence.

Featured Genetics Neuroscience

·August 14, 2019·3 min read

Scientists reverse aging process in rat brain stem cells

Removing Piezo1 from the surface of aged brain stem cells caused the cells to become rejuvenated and regain their normal regenerative function.

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·August 9, 2019·3 min read

How chronic stress causes brain damage

Chronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.

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·July 25, 2019·4 min read

To become, or not to become… a neuron

Bcl6 acts as a driver of neurogenic transition by directly silencing a selection of genes that belong to multiple extrinsic pathways promoting self-renewal. Bcl6 is only expressed in specific subsets of neurons and progenitor cells during brain development.

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·July 22, 2019·4 min read

Exosomes may hold the answer to treating and diagnosing developmental brain disorders

Exosomes carry signaling information required to regulate neural circuit development.

Featured Neurology Neuroscience

·July 15, 2019·2 min read

Reducing seizures by removing newborn neurons

Removing new neurons generates as a result of neurogenesis following brain injury reduced seizure activity in mouse models of mesial temporal lobe epilepsy.

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·July 11, 2019·5 min read

First step to induce self-repair in the central nervous system

Severed axonal segments signal to Schwann cells to begin actin sphere formation and axon disintegration. If the process is disrupted, axon disintegration is slowed and axon fragments impair nerve regeneration.

Featured Genetics Neurology Neuroscience

·July 3, 2019·6 min read

Immune cells invade aging brains, disrupt new nerve cell formation

Intrusive T cells have been discovered in the brain's neurogenic niches of older mice and humans. Findings suggest the T cells impair neurogenesis.

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·July 2, 2019·4 min read

Short bout of exercise enhances brain function

Short bursts of exercise, equivalent to a pick-up game of basketball, boosts the function of a gene that increases dendritic spines in the hippocampus, helping to improve memory and learning.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·June 25, 2019·5 min read

Alzheimer’s mouse model seizures disrupt adult neurogenesis

Seizures associated with Alzheimer's disease in both animal models and humans alter hippocampal neurogenesis. Treating mice with antiseizure medications normalized neurogenesis and improved spatial discrimination.

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