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antidepressants

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·June 18, 2019·3 min read

Antidepressants can reduce ’empathic empathy’

Antidepressants for major depressive disorder reduce the aversive response triggered by exposure to the suffering of others. Findings suggest antidepressants may lead to impaired empathy of pain perception.

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·June 3, 2019·4 min read

Antidepressants could be used to treat multiple bacterial infections

FIASMA antidepressants, such as amitriptyline and desipramine, halt the growth of four different kinds of bacterial pathogens in cell cultures and animal models. The antidepressants have shown to be effective in killing intracellular bacteria in two chlamydia infections, as well as human granulocytic anaplasmosis, a tick-borne disease that attacks white blood cells.

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·June 3, 2019·3 min read

Diabetes drug alleviates anxiety in mice

Metformin, a common diabetes medication, shows promise for the treatment of anxiety and depression.

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·May 22, 2019·3 min read

New therapeutic target for depression identified

A fragment of the neuropeptide Galanin appears to play a role in anhedonia in mouse models of depression. Galanin could be a potential target for the treatment of depression.

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·May 21, 2019·5 min read

Study supports effectiveness of new fast-acting antidepressant, esketamine nasal spray

Esketamine combined with antidepressants acts rapidly to help alleviate symptoms in those with treatment-resistant depression.

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·May 16, 2019·5 min read

Ketamine: The illicit party psychedelic that promises to heal depression

Ketamine, an anesthetics which has been commonly used as an illicit party drug, is helping people overcome depression. The drug works rapidly and provides lasting relief from depressive symptoms for weeks after exposure. Researchers are examining how ketamine works in the brain to help positively influence behavior in those with mood disorders.

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·May 10, 2019·4 min read

Dietary fats entering the brain may explain link between obesity and depression: Mouse study

A mechanism that links exposure to high-fat diets in mice to changes in hypothalamic function which leads to depression has been identified. Saturated fatty acids enter the brain via the bloodstream, where they accumulate and affect key signaling pathways associated with the development of depression.

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·May 2, 2019·4 min read

Newly discovered gene mutation reduces fear and anxiety, and increases social interaction

The Ph4-tm gene has been implicated in fear and anxiety. P4h-tm knockout mice showed diminished response to fear and showed more courageous behavior than wild-type mice with a functional P4h-tm gene.

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·April 30, 2019·4 min read

Possible link between autism and antidepressants use during pregnancy: Mouse Study

A new study in mice reveals a possible link between the use of SSRI antidepressants during pregnancy and an increased risk of autism-like symptoms in offspring. Offspring exposed to fluoxetine (Prozac) in utero were more likely to exhibit impaired neurotransmission caused by an overactive serotonin receptor in the prefrontal cortex, an area of the brain implicated in modulating social behaviors. However, treating the mice with a compound that blocks the receptor alleviated the behavioral problems and improved working memory.

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·April 18, 2019·5 min read

Fish are accumulating certain antidepressants, antibiotics and sun cream components

Antidepressants, such as the SSRI amitriptyline, antibiotics associated with developmental problems and sun cream components are contaminating water, and are being accumulated in fish. Exposure to the medications has effects on the molecular level to the fish. Researchers say this poses a problem as consumption of gilt-head bream is on the rise, and there could be a risk of the contaminants reaching humans via diet.

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·April 11, 2019·3 min read

Ketamine reverses neural changes underlying depression-related behaviors: Mouse study

The formation of prefrontal cortex dendritic spine formation sustains the remission of depressive related symptoms and behaviors following ketamine treatment by restoring lost spines.