Antidepressant use has been linked to thicker arteries, possibly contributing to the risk of heart disease and stroke, in a... Read More
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Southwestern Medical Center investigators have identified a genetic manipulation that increases the development of neurons in the brain during aging... Read More
Scientists have laid bare a novel molecular mechanism responsible for the major depression symptom, anhedonia, the loss of the ability to experience pleasure. The brain circuit involved in this newly elucidated pathway is largely identical between rodents and humans, upping the odds that the findings point toward new therapies for depression and other disorders. Additionally, opinion leaders hailed the study’s inventive methodology, saying it may offer a much sounder approach to testing new antidepressants. Read More
Neuroscientists found that astrocytes may be responsible for the rapid improvement in mood in depressed patients after acute sleep deprivation. This study identified how astrocytes can regulate a neurotransmitter involved in sleep. Read More
Researchers identify a protein that appears to be the target of both antidepressant drugs and electroconvulsive therapy. The experimental results explain how these therapies likely work to relieve depression by stimulating stem cells in the brain to grow and mature. Read More
A new study funded by the NIMH suggests GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the negative side effects of the well known street drug. Read More
A synthetic compound, decynium-22, is able to turn off SERT in the brain, enhancing the effectiveness of SSRIs. Read More
Researchers suggest serotonin metabolism in the pineal gland could play a role in the underlying cause of depression. The findings were based on biochemical changes which were seen to be in association with improvements in depression. Read More
Researchers identify a molecular pathway which accelerates the time taken for antidepressants to work in mouse models. Read More
According to new research, higher accumulation of Lithium occurs in the brain's white matter. Read More
Researchers discover a gene which may reveal how well a person is likely to respond to SSRI antidepressants. Read More
A common antidepressant proves effective in easing agitation associated with Alzheimer's disease, a new study reports. Read More
