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amyloid-beta

·September 9, 2021·5 min read

Reversal of the Biological Hallmarks Responsible for Development of Alzheimer’s Disease and Dementia Using Unique Hyperbaric Oxygen Therapy Protocol

Hyperbaric oxygen therapy improved cerebral blood flow by up to 23%, alleviating vascular dysfunction and amyloid burden in elderly patients. The treatment also improved memory by 16.5%.

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·September 1, 2021·5 min read

New Brain Model Provides Patient-Specific Alzheimer’s Insights and Predictions of Cognitive Decline

A newly developed brain model from cultivated stem cells allowed researchers to analyze molecular pathways of neurons in a dish. Researchers identified specific forms of amyloid beta and tau associated with cognitive decline and Alzheimer's. They also uncovered signaling pathways that influence the production of the toxic proteins.

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·August 23, 2021·4 min read

Eyes Provide Peek at Alzheimer’s Disease Risk

The presence of amyloid-beta deposits in the retina correlated with cerebral amyloid levels in those with Alzheimer's disease. The findings may lead to methods for the earlier detection of Alzheimer's.

This shows a brain made up of cog wheels and a light bulb

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·August 18, 2021·3 min read

Does Alzheimer’s Disease Start Inside Nerve Cells?

Amyloid-beta accumulates in nerve cells and spreads, from cell to cell, via nerve fibers. This process occurs prior to the formation of amyloid plaques in the brain.

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·August 14, 2021·5 min read

Brain Cholesterol Regulates Alzheimer’s Plaques

A new advanced imaging technique shows how cholesterol regulates the production of Alzheimer's associated amyloid beta proteins in astrocytes.

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·August 12, 2021·3 min read

Some Diabetes Drugs Reduce Risk and Symptoms of Alzheimer’s

Dipeptidyl peptidase-4 inhibitors, a class of drug that reduces blood sugar in type 2 diabetes, were associated with less amyloid accumulation in the brain and slower cognitive decline in patients.

This shows amyloid beta in a staining sample

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·August 7, 2021·3 min read

Miniature Brain Models Developed to Study the Causes of Alzheimer’s and Test Drugs in Development

Researchers have developed a new brain organoid model to study the mechanistic causes of Alzheimer's disease and test dementia drugs currently in development.

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·August 5, 2021·5 min read

Lower Blood Levels of Amyloid Beta 42 in Midlife Associated With Dementia Risk

Lower blood levels of amyloid-beta 42 during mid-life were associated with a higher risk of dementia and a marginally increased risk of mild cognitive impairment later in life, a new study reports.

This shows amyloid beta in hippocampal cells

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·July 30, 2021·4 min read

Molecular Insights Into Primate Hippocampal Aging

Study establishes a comprehensive single-nucleus transcriptomic atlas of the aging primate hippocampus and provides key information about age-related molecular signatures at the single-cell level.

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·June 28, 2021·5 min read

Prevailing Alzheimer’s Theory in Question With New Discovery

Study finds amyloid-beta plaques may not be the cause of memory loss associated with Alzheimer's disease, but instead a consequence of the disease. Regardless of the levels of amyloid plaques, researchers found individuals with high levels of amyloid peptide were cognitively normal. Higher levels of soluble amyloid beta peptide were also linked to people having a larger hippocampus.

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·June 16, 2021·6 min read

P-Glycoprotein Removes Alzheimer’s-Associated Toxin From the Brain

P-glycoprotein, a critical toxin pump in the body, has the ability to remove amyloid plaques from the brain. Researchers say increasing P-gp in the blood-brain barrier of those at risk for Alzheimer's could postpone or prevent the onset of the neurodegenerative disease.