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Brain Plasticity Restored in Adult Mice Through Targeting Specific Neural Connections

Summary: Researchers have identified a molecular mechanism which appears to be critical for the maturation of brain function, and may be used to restore plasticity in the aging brain. .

Source: Tufts University.

Neuroscientists at Tufts University School of Medicine, in collaboration with colleagues at Yale University School of Medicine, have discovered a new molecular mechanism that is essential for maturation of brain function and may be used to restore plasticity in aged brains. Unlike previous research that broadly manipulated brain plasticity using approaches that affected the entire brain, this study targets for the first time a specific molecule acting on a single type of neuronal connection to modulate brain function. This restores the brain’s ability to rewire itself.

The research in mice could advance understanding and treatment of human diseases such as autism spectrum disorders and stroke. It is published in Cell Reports on January 8, 2019.

The human brain is very plastic during childhood, and all young mammals have a “critical period” when different areas of their brains can remodel neural connections in response to external stimuli. Disruption of this precise developmental sequence results in serious damage; conditions such as autism potentially involve disrupted critical periods.

“It’s been known for a while that maturation of inhibitory nerve cells in the brain controls the onset of critical period plasticity, but how this plasticity wanes as the brain matures is not understood,” said Adema Ribic, Ph.D., research scientist at Tufts School of Medicine and first author of the new study. “We’ve had some evidence that a set of molecules called SynCAMs may be involved in this process, so we decided to dig deeper into those specific molecules.”

The study focused on the visual cortex, the part of the brain responsible for processing visual scenes, in which plasticity has been examined in many species. Using advanced viral tools and electrophysiological techniques, the researchers were able to measure activity of nerve cells (neurons) in awake mice freely responding to visual stimuli. They found that removal of the SynCAM 1 molecule from the brain increased plasticity in the visual cortex of both young and adult mice. Further research found that SynCAM 1 controls a very specific type of neuronal connection termed synapses: the long-distance synapses between the visual thalamus, located beneath the cerebral cortex, and inhibitory neurons in the cortex. SynCAM 1 was found to be necessary for the formation of synapses between thalamus and inhibitory neurons, which in turn helps inhibitory neurons to mature and actively restrict critical period plasticity.

Ribic likens inhibitory neurons to a dial controlling when brain plasticity can occur. Plasticity is needed during early development, as the function of different brain areas matures. Mature function is then ‘cemented’ into place by molecules like SynCAM 1.

“Our study identified a fundamental mechanism that controls brain plasticity, and perhaps most exciting, we can show that a process in the adult brain actively suppresses plasticity,” said study senior author Thomas Biederer, Ph.D., associate professor of neuroscience at Tufts School of Medicine and a member of the neuroscience program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts. “Therefore, the limited ability of the mature brain to change is not simply a consequence of age but is directly enforced by the SynCAM 1 mechanism. This allows us to target the mechanism to re-open plasticity in the mature brain, which could be relevant for treating disorders like autism.”

PV neurons

The study focused on a subtype of inhibitory cell also found in people called Parvalbumin neurons (stained in blue) which exert significant power over the timing of the “critical period” for brain maturation. NeuroscienceNews.com image is credited to Adema Ribic/Tufts University School of Medicine.

Focusing on a single molecule and synapse type to induce the heightened plasticity should support development of treatments with reduced potential for side effects. “For example, antidepressants may restore plasticity but will also have a lot of other effects,” said Ribic, who noted that more plasticity isn’t always better. “Our study found a way to increase plasticity in a very controlled way, both spatially and temporally. Combined with the latest approaches in genetic manipulation, this may prove to be a new path to tackle both childhood disorders and brain injury in adults.”

The researchers still need to determine if this plasticity mechanism will work in humans as well as mice and can be activated repeatedly. While there are obviously major differences between rodents and humans, studies in multiple species suggest that the general mechanisms of plasticity are similar.

The study is the latest work from the Biederer group at Tufts University School of Medicine, which focuses on mechanisms of synapse formation and plasticity in the context of normal development and neurodevelopmental disorders.

About this neuroscience research article

Funding: The work was supported by the National Institutes of Health’s National Institute on Drug Abuse (R01DA018928), National Eye Institute (R01EY015788, R01EY023105, P30EY026878), and National Institute of Neurological Disorders and Stroke (U01NS094358), and by the Knights Templar Eye Foundation.

Source: Kimberly Thurler – Tufts University
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Adema Ribic/Tufts University School of Medicine.
Original Research: Open access research for “Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1” by Adema Ribic, Michael C. Crair, and Thomas Biederer Journal of Consulting and Clinical Psychology. Published January 8 2019.
doi:10.1016/j.celrep.2018.12.069

Cite This NeuroscienceNews.com Article
Tufts University”How the Brain Decides Whether to Hold ’em or Fold ’em.” NeuroscienceNews. NeuroscienceNews, 7 January 2019.
<http://neurosciencenews.com/brain-plasticity-restoration-10466/>.
Tufts University(2019, January 7). How the Brain Decides Whether to Hold ’em or Fold ’em. NeuroscienceNews. Retrieved January 7, 2019 from http://neurosciencenews.com/brain-plasticity-restoration-10466/
Tufts University”How the Brain Decides Whether to Hold ’em or Fold ’em.” http://neurosciencenews.com/brain-plasticity-restoration-10466/ (accessed January 7, 2019).

Abstract

Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1

Cortical plasticity peaks early in life and tapers in adulthood, as exemplified in the primary visual cortex (V1), wherein brief loss of vision in one eye reduces cortical responses to inputs from that eye during the critical period but not in adulthood. The synaptic locus of cortical plasticity and the cell-autonomous synaptic factors determining critical periods remain unclear. We here demonstrate that the immunoglobulin protein Synaptic Cell Adhesion Molecule 1 (SynCAM 1/Cadm1) is regulated by visual experience and limits V1 plasticity. Loss of SynCAM 1 selectively reduces the number of thalamocortical inputs onto parvalbumin (PV+) interneurons, impairing the maturation of feedforward inhibition in V1. SynCAM 1 acts in PV+ interneurons to actively restrict cortical plasticity, and brief PV+-specific knockdown of SynCAM 1 in adult visual cortex restores juvenile-like plasticity. These results identify a synapse-specific, cell-autonomous mechanism for thalamocortical visual circuit maturation and closure of the visual critical period.

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