Post-genomic analysis of the regulation of synapses in a rodent hippocampus sheds new light on the interaction of proteins and lipids within the synaptic membrane.
A new study expands the understanding of how brain cells communicate. Researchers discovered reversing the modification of molecular messages at the synapse may contribute to reversible psychiatric disorders and early-stage neurodegenerative diseases.
The planar cell polarity (PCP) signaling pathway appears to play a significant role in the formation and maintenance of a large number of synapses.
Researchers identified key alterations in gene expression and structure of the developing human brain that makes it unique among other animal species.
Schizophrenia itself is associated with loss of excitation, but hallucinations and other symptoms of the disorder are caused by a loss of synaptic inhibition.
Study identifies the main components driving amyloid beta-associated synaptic degeneration.
Thrombospondin-2, a protein with cell adhesion properties usually secreted by astrocytes, prompted a strong increase in synapses in male-derived neurons but showed no effect in females.
Study sheds new light on the role noncoded RNAs play at the synapse.
A new whole-genome sequencing study has revealed thirteen novel genes associated with Alzheimer's disease. Researchers also found a new link between Alzheimer's and synaptic function.
Findings shed new light on how the brain wires during development.
A new theory of memory visualizes the brain as an organic super-computer that runs complex binary code with neurons acting like mechanical computers. The theory is based on the discovery of the protein molecule, talin, which contains switch-like domains that change shape in response to pressure in mechanical force by a cell.
Over-expression of the synaptic protein RAPGEF2 drives synaptic loss associated with Alzheimer's disease.
