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synapses

·September 15, 2023·6 min read

Parkinson’s Onset Theory Challenged: Synaptic Dysfunction Before Neuron Death

Contrary to the widely held belief that Parkinson’s disease originates from the degeneration of dopaminergic neurons, a new study suggests a precursor: synaptic dysfunction. This revelation unveils the dysfunction of dopaminergic synapses prior to neurodegeneration.

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·June 14, 2023·5 min read

Unprecedented 3D Synapse Imaging to Combat Neurodegenerative Diseases

Researchers developed one of the most comprehensive 3D models of the synapse, the neuron juncture crucial for intercellular communication. This breakthrough allows an unprecedented view of the complex interactions between individual cells at the synapse, offering fresh insights into neurodegenerative diseases such as Huntington's disease and schizophrenia.

Featured Neuroscience

·May 25, 2023·3 min read

Moonlighting Proteasome: Unraveling a Novel Role in Brain Synapses

Researchers reveal a previously unknown role of the 19S regulatory particle, part of the cellular proteasome machinery, at the synapses in the brain. These particles were found to be independently regulating synaptic proteins without the presence of their usual partner, the 20S catalytic particle. This independent function of 19S, described as "moonlighting", could help synapses adapt to various conditions.

Featured Neuroscience Open Neuroscience Articles

·February 18, 2023·2 min read

In Vivo Synaptic Dynamics in Various Memory States

Researchers have identified the in-vivo dynamics of synapses that underlie fear memory formation and extinction in the living brain.

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·February 2, 2023·7 min read

Sparse, Small, but Diverse Neural Connections Help Make Perception Reliable and Efficient

Thalamic inputs into superficial layers of the cerebral cortex are both rare and weak, yet surprisingly diverse in their distribution patterns. However, they are reliable and efficient representatives of information.

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·January 20, 2023·11 min read

A New Field of Neuroscience Aims to Map Connections in the Brain

Connectomics researchers aim to map and understand how individual neurons connect to each other to form functional networks.

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·January 17, 2023·7 min read

How a Unique, Fast Synapse Keeps Us From Falling

Study opens the door for the exploration of information processing in vestibular synapses.

Featured Neuroscience Psychology

·January 13, 2023·4 min read

The Dynamics of Memory-Encoding Synapses in the Brains of Live Mice

Researchers used neuroimaging technology to show the creation and elimination of synapses between neurons in the brains of living mice. The findings provide insight into what happens when memories are created and forgotten. The research could pave the way for new treatments for PTSD.

Featured Genetics Neuroscience Visual Neuroscience

·January 4, 2023·5 min read

Lab-Grown Retinal Cells Open the Door to Treat Blindness and Degenerative Eye Diseases

Lab-created retinal cells created from human stem cells can reach out and connect to neighboring cells, a new study reports. The cells have the capacity to replace damaged retinal cells and carry sensory information. The findings could pave the way for clinical trials for the treatment of a range of diseases associated with vision loss and blindness.

This shows the outline of a head and a brain

Featured Neuroscience Open Neuroscience Articles

·December 29, 2022·7 min read

Holding Information in Mind May Mean Storing It Among Synapses

Findings support modern thought that neural networks store information by making short-term alterations to the synapses. The study sheds new light on short-term synaptic plasticity in recent memory storage.

Featured Neuroscience

·November 25, 2022·3 min read

Essential Signaling Pathway for Neuronal Connectivity During Brain Development Identified

Study reveals a signaling pathway that controls the formation of synapses between pyramidal neurons and inhibitory neurons expressing the parvalbumin protein.