Chandelier cells have an unusual direct method of communication. Unlike other neurons, chandelier cells connect directly to the part of a target neuron that initiates a spike.
Strengthened amygdala pathways increase aggression in those who have experienced trauma. The findings could lead to new treatments for PTSD.
Learning produces changes in connectivity via multiple synaptic mechanisms that are consistent with observed behavioral changes.
Study reveals how mutations of the synaptotagmin-1 protein can lead to a rare disorder called syt1-associated neurodevelopmental disorder. Mutations of the SYT1 gene interfere with neurotransmitter release, and the altered protein becomes less responsive to calcium.
The direct contact of mGluR4 receptors with other key proteins plays a significant role in the regulation of synaptic activity.
An over-production of eIF4E impairs microglial cells, hampering their ability to effectively prune synapses and leading to autism-like behaviors in male mouse models of ASD.
Study shows how Toxoplasma parasitic infections promote the loss of inhibitory signaling in the brain by altering the behavior of microglia.
Combining two-photon fluorescent microscopy and all-optical laser scanning, researchers can image the brain of an alert mouse 1,000 times a second, recording the passage of millisecond electrical pulses through neurons.
Using optogenetics to inhibit the JNK protein prevented synapses from shrinking in response to stress.
Enhancing mitochondrial transportation and cellular energetics could help promote regeneration and function following spinal cord injury.
A single neuron, through its axon, is capable of simultaneously producing different effects in separate areas of the cerebral cortex.
Study reports repeats in genes associated with Fragile X syndrome normally regulate how and when proteins are made in neurons.
