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Western Diet Increases Alzheimer’s Pathology in Genetically Predisposed Mice

Summary: Diet and lifestyle changes could lower the risk of developing Alzheimer’s disease for those who are genetically predisposed, a new study suggests.

Source: SfN.

Obese mice with a particular version of a gene strongly associated with Alzheimer’s disease (AD) in humans show increased Alzheimer’s pathology, according to new research published in eNeuro. The study suggests lifestyle changes could reduce the likelihood of developing AD in individuals with this genetic predisposition.

Individuals who inherit the gene APOE4 — approximately 12 percent of the U.S. population — have an increased risk of late-onset AD, but not all carriers develop the disease. Although the role of APOE4 in AD is not known, environmental factors that also increase risk of dementia, such as obesity, may contribute to development of AD.

Christian Pike and Alexandra Moser investigated the interaction between APOE4 and obesity in a mouse model of AD, in which some male mice carry the human version of APOE4 and others carry the more common human version APOE3. The authors found that APOE4-carrying mice fed a Western-like diet high in saturated fat and sugars for 12 weeks had increased deposits of β-amyloid protein as well a greater number of glial cells, characteristic of AD. These changes were not observed in mice carrying APOE3, which could mean that carriers of APOE4 are more susceptible to the effects of obesity on AD.

Image shows a diagram of an alzheimer's brain slice.

The authors found that APOE4-carrying mice fed a Western-like diet high in saturated fat and sugars for 12 weeks had increased deposits of β-amyloid protein as well a greater number of glial cells, characteristic of AD. NeuroscienceNews.com image is for illustrative purposes only.

About this neuroscience research article

Source: SfN
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: The study will appear in eNeuro.

Cite This NeuroscienceNews.com Article
SfN “Western Diet Increases Alzheimer’s Pathology in Genetically Predisposed Mice.” NeuroscienceNews. NeuroscienceNews, 12 June 2017.
<http://neurosciencenews.com/western-diet-alzheimers-6893/>.
SfN (2017, June 12). Western Diet Increases Alzheimer’s Pathology in Genetically Predisposed Mice. NeuroscienceNew. Retrieved June 12, 2017 from http://neurosciencenews.com/western-diet-alzheimers-6893/
SfN “Western Diet Increases Alzheimer’s Pathology in Genetically Predisposed Mice.” http://neurosciencenews.com/western-diet-alzheimers-6893/ (accessed June 12, 2017).
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