Inhibiting the NHE6 gene abolished the formation of amyloid-beta plaques in mouse models of Alzheimer's disease.
Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.
Post mortem examinations of brain tissue from Alzheimer's patients revealed synapses contained clumps of clusterin, in addition to amyloid beta. The clumps were more abundant in those with genetic risk factors from Alzheimer's disease.
Researchers say promoting conversion of glucose into brain energy could reduce risk factors and delay disease onset for those who carry Alzheimer's associated genes.
A new study adds to growing evidence that early exposure to pollution can increase both suicide risks in younger people and Alzheimer's disease as people age.
Researchers report they have successfully erased damage caused by Apoe4 in Alzheimer's patients by altering the gene into a harmless Apoe3-like version.
Diet and lifestyle changes could lower the risk of developing Alzheimer's disease for those who are genetically predisposed, a new study suggests.
Researchers suggest the ApoE gene could be a promising new target for therapeutic approaches for Alzheimer's disease.
ApoE2 appears to have neuroprotective properties and could be key in the fight against Alzheimer's disease, according to a new study.
A new study reports even low levels of APOE4 can increase beta-amyloid plaques in the brain and neuronal damage in mouse models of Alzheimer's disease. However, introducing APOE2 can reduce amyloid deposits and other associated damage.
