ApoE3

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ApoE3

This shows tissue samples from the study

Featured Genetics Neurology Neuroscience

·November 16, 2022·7 min read

Alzheimer’s Risk Gene Undermines Insulation of Brain’s ‘Wiring’

When people carry the Alzheimer's associated APOE4 gene, oligodendrocytes fail to transport fatty molecules to wrap neurons that make brain circuitry connections. This deficit of myelin may contribute to the pathology and symptoms of Alzheimer's disease.

This is an illustration of neurons, amyloid plaques and tau

Featured Neurology Neuroscience

·October 29, 2021·4 min read

Key Alzheimer’s Feature Eliminated in Animal Model

Inhibiting the NHE6 gene abolished the formation of amyloid-beta plaques in mouse models of Alzheimer's disease.

Featured Genetics Neurology Open Neuroscience Articles

·September 15, 2021·3 min read

Stem Cells Model Genetic Risk for Developing Alzheimer’s Disease

Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·June 27, 2019·3 min read

Dementia study links gene with damage to brain connections

Post mortem examinations of brain tissue from Alzheimer's patients revealed synapses contained clumps of clusterin, in addition to amyloid beta. The clumps were more abundant in those with genetic risk factors from Alzheimer's disease.

Featured Genetics Neurology

·July 2, 2018·3 min read

Unraveling Genetic Risk Factors for Alzheimer’s

Researchers say promoting conversion of glucose into brain energy could reduce risk factors and delay disease onset for those who carry Alzheimer's associated genes.

Featured Neurology Neuroscience Psychology

·April 14, 2018·4 min read

Evidence Mounts for Increased Alzheimer’s and Suicide Risks in Polluted Cities

A new study adds to growing evidence that early exposure to pollution can increase both suicide risks in younger people and Alzheimer's disease as people age.

Featured Genetics Neurology

·April 9, 2018·5 min read

Researchers Fix Genetic Risk Factor of Alzheimer’s in Human Brain Cells

Researchers report they have successfully erased damage caused by Apoe4 in Alzheimer's patients by altering the gene into a harmless Apoe3-like version.

Image shows a diagram of an alzheimer's brain slice.

Featured Neurology

·June 12, 2017·1 min read

Western Diet Increases Alzheimer’s Pathology in Genetically Predisposed Mice

Diet and lifestyle changes could lower the risk of developing Alzheimer's disease for those who are genetically predisposed, a new study suggests.

Featured Genetics Neurology

·October 5, 2016·4 min read

Enzyme Treatment of Gene May Reverse Effects of Alzheimer’s

Researchers suggest the ApoE gene could be a promising new target for therapeutic approaches for Alzheimer's disease.

This shows a plastinated alzheimer's brain.

Featured Genetics Neurology

·September 9, 2015·5 min read

Researchers Discover a Potential Protective Shield From Alzheimer’s Disease

ApoE2 appears to have neuroprotective properties and could be key in the fight against Alzheimer's disease, according to a new study.

The image is a diagram comparing the difference between neuron damage and associated damage in alzheimer's disease with normal neurons.

Featured Neurology

·November 20, 2013·5 min read

Study Reveals How Variant Forms of APOE Protein Impact Risk of Alzheimer’s Disease

A new study reports even low levels of APOE4 can increase beta-amyloid plaques in the brain and neuronal damage in mouse models of Alzheimer's disease. However, introducing APOE2 can reduce amyloid deposits and other associated damage.