obesity

This shows pizza, burgers and other junk foods

Dietary fats entering the brain may explain link between obesity and depression: Mouse study

A mechanism that links exposure to high-fat diets in mice to changes in hypothalamic function which leads to depression has been identified. Saturated fatty acids enter the brain via the bloodstream, where they accumulate and affect key signaling pathways associated with the development of depression.... Read More...
This shows neurons in the central amygdala

Comfort food leads to more weight gain during stress

A combination of chronic stress and high-calorie diets raised insulin levels tenfold in the amygdala of mice. Prolonged high levels of insulin in the central amygdala resulted in neurons becoming desensitized to insulin. The desensitized neurons boosted NPY levels, which promoted eating and reduced the normal homeostasis response to burn calories. The findings may shed light on why some indulge in high-calorie foods when stressed, and why this may lead to obesity.... Read More...
neurons in the CeA are shown

The neurobiology of noshing: Why is it so easy to overeat calorie-rich tasty foods?

Prepronociceptin expressing neurons in the central amygdala become activated by consuming palatable foods. Reducing nociceptin making neurons in mice reduced binge eating when the animals had access to calorie-rich foods, without affecting the intake of ordinary dietary needs. The finding could help in the development of new therapies to combat obesity and binge eating. ... Read More...
This shows the differences in ceramide levels in those with a higher BMI

Body mass index may play a significant role in the progression of multiple sclerosis

Obesity and a higher body mass index negatively impacts the progression of Multiple Sclerosis. Ceramides are more abundant in the blood of those who are overweight. The ceramides enter inside the nucleus of monocytes, causing proliferation. The increased number of monocytes travel back to the brain, causing more damage for those with RRMS.... Read More...