ApoE4

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ApoE4

·June 23, 2020

New gene may drive earliest brain changes in Alzheimer’s

Genetic analysis of almost 4,300 samples reveals a link between the appearance of amyloid deposits, APOE, and a novel gene called RBFOX1. Lower levels of RBFOX1 in the brain appear to be associated with increased amyloid and global cognitive decline over a person's lifetime. Read More

Featured Genetics Neurology Neuroscience

·April 29, 2020

APOE4 triggers early breakdowns in the blood-brain barrier

APOE4, a gene implicated as a risk factor for Alzheimer's disease, triggers leaks in the blood-brain barrier. The damage to capillaries APOE4 causes correlates with increased levels of cyclophilin, a protein that causes the inflammation that is a signature of early Alzheimer's. Read More

Featured Genetics Neurology Neuroscience

·April 13, 2020

Gene variant staves off Alzheimer’s in some people

Carriers of one copy of the longevity associated klotho gene reduces Alzheimer's risks by 30% for those with genetic risk factors for the neurodegenerative disease. Read More

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·September 16, 2019

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia. Read More

Featured Neurology Neuroscience

·September 13, 2019

What multilingual nuns can tell us about dementia

While being multilingual did not delay the onset of dementia for those at risk, nuns who spoke four or more languages were significantly less likely to develop dementia than those who spoke just one language. Read More

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·August 22, 2019

Carriers of Alzheimer’s genetic marker have greater difficulty harnessing past knowledge

Middle-aged people with the Alzheimer's related APOE4 gene have a harder time accessing recently acquired knowledge, even when they show no symptoms of memory decline. Read More

This shows a researcher performing analyzes of blood work

Featured Neurology Neuroscience

·August 2, 2019

Blood test 94% accurate at identifying Alzheimer’s before symptoms appear

A new blood test for Alzheimer's disease is up-to 94% accurate at predicting dementia before symptoms appear. The test's accuracy is increased when genetic predisposition and age are taken into account. The new test may eventually replace PET neuroimaging, currently considered the gold standard, for early detection of Alzheimer's. Read More

Featured Genetics Neurology Neuroscience

·July 20, 2019

Lower childhood IQ linked to Alzheimer’s later in life

Children with the APOE E4 gene perform lower on verbal and general IQ tests than their peers without the genetic risk factor. APOE E4 is a genetic risk factor for Alzheimer's disease. The study suggests the effects of the gene manifests before adulthood and could be the earliest biomarker for later vulnerability to Alzheimer's disease. Read More

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·June 27, 2019

Dementia study links gene with damage to brain connections

Post mortem examinations of brain tissue from Alzheimer's patients revealed synapses contained clumps of clusterin, in addition to amyloid beta. The clumps were more abundant in those with genetic risk factors from Alzheimer's disease. Read More

Featured Neurology Neuroscience

·January 7, 2019

Racial Differences in Alzheimer’s Unveiled

A new study has identified racial disparities between African Americans and Caucasians in the level of a key biomarker used to identify Alzheimer's disease. Read More

Featured Neurology Neuroscience Open Neuroscience Articles

·December 17, 2018

A Pathway to a Vaccine and Drugs for Late Onset Alzheimer’s

Researchers have successfully neutralized a genetic risk factor found in up to 80% of Alzheimer's patients. The ability to neutralize ApoE4 could help in the development of a vaccine, as well as other therapeutics, for late onset Alzheimer's. Read More

Featured Genetics Neurology

·December 5, 2018

Alzheimer’s Patients Classified in Six Subgroups

Researchers have identified cognitive subgroups related to genetic differences in Alzheimer's patients. The findings, researchers say, could open the door for more personalized treatments of the neurodegenerative disease. Read More

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