Taking a vitamin D supplement daily may help stave off dementia in older adults, a new study reports. Researchers found taking vitamin D was associated with adults living dementia free for longer, and there were 40% fewer cases of dementia reported in those who frequently took vitamin D supplements. The effects were significantly greater in women than men.
Hormone replacement therapy (HRT) use was associated with better cognition, memory, and larger brain volume in women who carry the Alzheimer's associated APOE4 genetic variant.
When people carry the Alzheimer's associated APOE4 gene, oligodendrocytes fail to transport fatty molecules to wrap neurons that make brain circuitry connections. This deficit of myelin may contribute to the pathology and symptoms of Alzheimer's disease.
Parts of the brain in which the APOE gene is most active are the areas that sustain the most damage associated with Alzheimer's disease.
Boosting omega-3 fatty acid intake helps to preserve brain health and improve cognition in middle age, a new study reports. For those with the Alzheimer's associated APOE4 gene, omega-3 fatty acid intake was associated with greater hippocampal volume and less small vessel disease.
Mice with the Alzheimer's disease-associated APOE4 and the APOE2 genes were more likely to die from COVID-19 than those with the APOE3 gene. Those with APOE4 and APOE2 genes had more virus replication in the lungs, higher inflammation, and increased tissue damage following coronavirus infection.
Microglia that express the Alzheimer's associated APOE4 genetic variant are unable to effectively metabolize lipids. This causes lipids to build up, promoting inflammation and preventing effective neurotransmission.
Changes in the Retina Can Be Linked to Parts of the Brain of Healthy Subjects at Risk of Alzheimer’s
In cognitively healthy people with a genetic risk for Alzheimer's, retinal changes have been associated with alterations in the entorhinal cortex, hippocampus, and lingual gyrus. Researchers say retinal changes can be used to track changes in brain structures associated with Alzheimer's in those with genetic risk factors.
The genetic background around APOE region can modify the Alzheimer's disease-associated APOE4 risk effects.
People with higher levels of omega-3 DHA in their blood are 49% less likely to develop dementia than those with lower levels. Researchers say adding additional omega-3 DHA to the diet, especially in those with the Alzheimer's associated Apoe4 gene, could slow the development and progress of dementia.
A new study outlines and defines sex differences in outcomes of tailored Alzheimer's disease clinical interventions.
15 newly discovered "hotspots" in the genome that either speed up or slow down brain aging could be new targets for the development of Alzheimer's medications and therapies for other brain disorders.