Altered pain perception could be a new biomarker to assess late-onset Alzheimer's risk in cognitively healthy individuals with the AopE4 gene before symptoms occur. Read More
People with the APOE4 genetic risk factor for Alzheimer's disease also have lower levels of the CRP inflammatory molecules in their spinal fluid. Researchers speculate these inflammatory molecules may be accumulating in the brain and causing damage, rather than floating freely in cerebrospinal fluid. Read More
ApoE4, a gene associated with an increased risk of Alzheimer's disease, also appears to increase susceptibility and the severity of COVID-19. SARS-CoV-2, the virus responsible for coronavirus, increased susceptibility to COVID-19 in ApoE4 neurons and astrocytes in brain organoid models. Read More
The Alzheimer's risk gene ApoE4 hampers the process of endocytosis in astrocytes. Read More
APOEe4, a gene associated with Alzheimer's disease risk, doesn't appear to directly affect memory performance or brain activity in older adults without cognitive impairment. However, the gene does seem to influence brain regions and systems that older at-risk adults activate to support successful memory recall. Read More
Genetic analysis of almost 4,300 samples reveals a link between the appearance of amyloid deposits, APOE, and a novel gene called RBFOX1. Lower levels of RBFOX1 in the brain appear to be associated with increased amyloid and global cognitive decline over a person's lifetime. Read More
APOE4, a gene implicated as a risk factor for Alzheimer's disease, triggers leaks in the blood-brain barrier. The damage to capillaries APOE4 causes correlates with increased levels of cyclophilin, a protein that causes the inflammation that is a signature of early Alzheimer's. Read More
Carriers of one copy of the longevity associated klotho gene reduces Alzheimer's risks by 30% for those with genetic risk factors for the neurodegenerative disease. Read More
APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia. Read More
While being multilingual did not delay the onset of dementia for those at risk, nuns who spoke four or more languages were significantly less likely to develop dementia than those who spoke just one language. Read More
Middle-aged people with the Alzheimer's related APOE4 gene have a harder time accessing recently acquired knowledge, even when they show no symptoms of memory decline. Read More
A new blood test for Alzheimer's disease is up-to 94% accurate at predicting dementia before symptoms appear. The test's accuracy is increased when genetic predisposition and age are taken into account. The new test may eventually replace PET neuroimaging, currently considered the gold standard, for early detection of Alzheimer's. Read More
