ApoE4

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ApoE4

This shows tissue samples from the study

Featured Genetics Neurology Neuroscience

·November 16, 2022·7 min read

Alzheimer’s Risk Gene Undermines Insulation of Brain’s ‘Wiring’

When people carry the Alzheimer's associated APOE4 gene, oligodendrocytes fail to transport fatty molecules to wrap neurons that make brain circuitry connections. This deficit of myelin may contribute to the pathology and symptoms of Alzheimer's disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·November 16, 2022·6 min read

Why Alzheimer’s Disease Damages Certain Parts of the Brain

Parts of the brain in which the APOE gene is most active are the areas that sustain the most damage associated with Alzheimer's disease.

Featured Neurology Neuroscience

·October 5, 2022·3 min read

Omega-3’s Linked to Improved Brain Structure and Cognition at Midlife

Boosting omega-3 fatty acid intake helps to preserve brain health and improve cognition in middle age, a new study reports. For those with the Alzheimer's associated APOE4 gene, omega-3 fatty acid intake was associated with greater hippocampal volume and less small vessel disease.

Featured Genetics Neuroscience

·September 21, 2022·6 min read

Common Alzheimer’s Gene Variant Linked to COVID Mortality

Mice with the Alzheimer's disease-associated APOE4 and the APOE2 genes were more likely to die from COVID-19 than those with the APOE3 gene. Those with APOE4 and APOE2 genes had more virus replication in the lungs, higher inflammation, and increased tissue damage following coronavirus infection.

Featured Neurology Neuroscience

·August 4, 2022·6 min read

How Microglia Contribute to Alzheimer’s Disease

Microglia that express the Alzheimer's associated APOE4 genetic variant are unable to effectively metabolize lipids. This causes lipids to build up, promoting inflammation and preventing effective neurotransmission.

Featured Genetics Neurology Visual Neuroscience

·July 26, 2022·4 min read

Changes in the Retina Can Be Linked to Parts of the Brain of Healthy Subjects at Risk of Alzheimer’s

In cognitively healthy people with a genetic risk for Alzheimer's, retinal changes have been associated with alterations in the entorhinal cortex, hippocampus, and lingual gyrus. Researchers say retinal changes can be used to track changes in brain structures associated with Alzheimer's in those with genetic risk factors.

Featured Genetics Neurology Neuroscience

·June 23, 2022·3 min read

Untangling the APOE4 Gene, the Most Significant Genetic Risk Factor for Alzheimer’s Disease

The genetic background around APOE region can modify the Alzheimer's disease-associated APOE4 risk effects.

Featured Neurology Neuroscience

·June 9, 2022·3 min read

People With a High Omega-3 DHA Level in Their Blood Are at 49% Lower Risk of Alzheimer’s

People with higher levels of omega-3 DHA in their blood are 49% less likely to develop dementia than those with lower levels. Researchers say adding additional omega-3 DHA to the diet, especially in those with the Alzheimer's associated Apoe4 gene, could slow the development and progress of dementia.

Featured Neurology Neuroscience

·April 26, 2022·6 min read

When It Comes to Preventing Alzheimer’s, Women and Men Are Not Created Equal

A new study outlines and defines sex differences in outcomes of tailored Alzheimer's disease clinical interventions.

Featured Genetics Neurology Neuroscience

·April 5, 2022·3 min read

Genetic ‘Hotspots’ That Speed up and Slow Down Brain Aging Could Provide New Targets for Alzheimer’s Drugs

15 newly discovered "hotspots" in the genome that either speed up or slow down brain aging could be new targets for the development of Alzheimer's medications and therapies for other brain disorders.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·December 29, 2021·4 min read

A Common Risk Factor for Alzheimer’s Disease May Predispose Carriers to Severe COVID-19

Carriers of the Alzheimer's associated APOE4 gene have more than double the risk of developing severe COVID-19, a new study reports. Additionally, more microscopic hemorrhages were found in the brains of APOE4 carriers who contracted coronavirus. Researchers report those with the APOE4 gene also are more susceptible to developing long-term symptoms following COVID infection, including an increased risk of mental fatigue.

Featured Genetics Neurology Neuroscience

·December 28, 2021·5 min read

Neuroprotective Mechanism Altered by Alzheimer’s Disease Risk Genes

In fruit fly models, an ABCA1 agonist can restore specific alterations of neuroprotective mechanisms associated with a genetic predisposition to Alzheimer's disease.

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