ApoE4

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ApoE4

Featured Genetics Neurology Open Neuroscience Articles

·September 15, 2021·3 min read

Stem Cells Model Genetic Risk for Developing Alzheimer’s Disease

Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.

Featured Neurology Neuroscience

·June 25, 2021·4 min read

Subconscious Changes in Movement May Predict Alzheimer’s Disease

Subtle changes in fractal motor activity regulation in cognitively healthy women may be a sign of preclinical Alzheimer's disease, researchers report.

Featured Genetics Neurology Psychology

·June 17, 2021·3 min read

Depression and Tau Deposits Seen in Subset of Middle-Aged Persons

Depressed middle-aged carriers of the APOEe4 Alzheimer's genetic variant are at risk of developing tau accumulations in brain areas associated with emotion and memory.

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Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·June 1, 2021·4 min read

Healthy Lifestyle Linked to Better Cognition for Oldest Adults, Regardless of Genetic Risk

Adults over 80 who maintained a healthy lifestyle, including exercise and diet, had a lower risk of cognitive decline, even if they had genetic risk factors for dementia.

Featured Neurology Neuroscience Visual Neuroscience

·May 14, 2021·5 min read

The Eyes Offer a Window Into Alzheimer’s Disease

Retinal scans can help researchers detect Alzheimer's disease and track its progression in those with the APOE4 genetic risk factor for the neurodegenerative disorder. The scans can detect blood vessel deterioration linked to the genetic biomarker.

Featured Genetics Neurology Neuroscience

·May 6, 2021·3 min read

Discovery of Genetic Drivers Linked to Progression in Parkinson’s Disease

Researchers identify five genetic loci linked to the progression of Parkinson's disease.

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Featured Neurology Neuroscience

·March 31, 2021·2 min read

Exercise May Help Slow Cognitive Decline in Some People With Parkinson’s Disease

Exercise helped to reduce cognitive decline two years later in Parkinson's patients with the APOE e4 gene variant.

Featured Genetics Neurology Neuroscience

·March 18, 2021·4 min read

Could Leak in Blood-Brain Barrier Be Cause of Poor Memory?

Researchers investigate the role the blood-brain barrier may play in age-related memory problems.

Featured Genetics Neurology Neuroscience

·March 3, 2021·5 min read

Why the APOE4 Gene Enhances Alzheimer’s Risk

APOE4 affects lipid metabolism, but taking choline supplements may help protect carriers from developing Alzheimer's disease and slow cognitive decline.

This shows a doctor looking at a spinal cord x ray

Featured Neurology Neuroscience

·February 26, 2021·5 min read

The Impact of Patient Sex on Treatment Strategies for Spinal Cord Injuries

Both the ApoE genotype and the sex of the mouse impacted the manner in which the animals with spinal cord injury responded to hypoxia treatment. Females with the ApoE e4 gene had a negative response to intermittent hypoxia.

This shows an older man holding his head in pain

Featured Genetics Neurology Neuroscience Pain

·February 24, 2021·4 min read

Pain Perception Could Help Diagnose Alzheimer’s Before Symptoms Occur

Altered pain perception could be a new biomarker to assess late-onset Alzheimer's risk in cognitively healthy individuals with the AopE4 gene before symptoms occur.

Featured Genetics Neurology

·February 11, 2021·5 min read

Spinal Fluid of People With Alzheimer’s Risk Gene Signals Inflammation

People with the APOE4 genetic risk factor for Alzheimer's disease also have lower levels of the CRP inflammatory molecules in their spinal fluid. Researchers speculate these inflammatory molecules may be accumulating in the brain and causing damage, rather than floating freely in cerebrospinal fluid.

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