Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.
Subtle changes in fractal motor activity regulation in cognitively healthy women may be a sign of preclinical Alzheimer's disease, researchers report.
Adults over 80 who maintained a healthy lifestyle, including exercise and diet, had a lower risk of cognitive decline, even if they had genetic risk factors for dementia.
Retinal scans can help researchers detect Alzheimer's disease and track its progression in those with the APOE4 genetic risk factor for the neurodegenerative disorder. The scans can detect blood vessel deterioration linked to the genetic biomarker.
Exercise helped to reduce cognitive decline two years later in Parkinson's patients with the APOE e4 gene variant.
Both the ApoE genotype and the sex of the mouse impacted the manner in which the animals with spinal cord injury responded to hypoxia treatment. Females with the ApoE e4 gene had a negative response to intermittent hypoxia.
People with the APOE4 genetic risk factor for Alzheimer's disease also have lower levels of the CRP inflammatory molecules in their spinal fluid. Researchers speculate these inflammatory molecules may be accumulating in the brain and causing damage, rather than floating freely in cerebrospinal fluid.