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ApoE4

Featured Genetics Neurology Neuroscience

·April 5, 2022·3 min read

Genetic ‘Hotspots’ That Speed up and Slow Down Brain Aging Could Provide New Targets for Alzheimer’s Drugs

15 newly discovered "hotspots" in the genome that either speed up or slow down brain aging could be new targets for the development of Alzheimer's medications and therapies for other brain disorders.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·December 29, 2021·4 min read

A Common Risk Factor for Alzheimer’s Disease May Predispose Carriers to Severe COVID-19

Carriers of the Alzheimer's associated APOE4 gene have more than double the risk of developing severe COVID-19, a new study reports. Additionally, more microscopic hemorrhages were found in the brains of APOE4 carriers who contracted coronavirus. Researchers report those with the APOE4 gene also are more susceptible to developing long-term symptoms following COVID infection, including an increased risk of mental fatigue.

Featured Genetics Neurology Neuroscience

·December 28, 2021·5 min read

Neuroprotective Mechanism Altered by Alzheimer’s Disease Risk Genes

In fruit fly models, an ABCA1 agonist can restore specific alterations of neuroprotective mechanisms associated with a genetic predisposition to Alzheimer's disease.

This shows a model of a head and a brain

Featured Neurology Neuroscience

·November 27, 2021·5 min read

New Framework for Analyzing Alzheimer’s Disease Identifies Not One Form, but Three

A new framework reveals Alzheimer's disease is far more complex than previously believed. Rather than being a disease where the same causes produce the same outcomes, researchers found three different models for the disease, each with its own characterizations and dynamics.

Featured Neurology Neuroscience

·November 10, 2021·3 min read

Repurposing Cancer Drug to Treat Alzheimer’s in Those With Genetic Risk Factors

Dasatinib, an FDA-approved drug for chronic myeloid leukemia, and an experimental drug for liver cancer reduced neuroinflammation, tau phosphorylation, and amyloid secretion in cell cultures of post-mortem brain samples of those with the APOE4 Alzheimer's associated gene.

This is an illustration of neurons, amyloid plaques and tau

Featured Neurology Neuroscience

·October 29, 2021·4 min read

Key Alzheimer’s Feature Eliminated in Animal Model

Inhibiting the NHE6 gene abolished the formation of amyloid-beta plaques in mouse models of Alzheimer's disease.

Featured Neurology Neuroscience

·October 20, 2021·6 min read

Hit the Sleep Sweet Spot to Keep Brain Sharp

Too much or too little sleep were both linked to increased risk of cognitive decline, researchers report.

Featured Neurology Neuroscience

·October 11, 2021·3 min read

Water Pill May Be Viable to Test as Alzheimer’s Treatment

Bumetanide, an FDA-approved potent diuretic used to treat fluid retention caused by heart, kidney, and liver disease may lower the risk of developing Alzheimer's disease for those with a genetic predisposition.

Featured Genetics Neurology Open Neuroscience Articles

·September 15, 2021·3 min read

Stem Cells Model Genetic Risk for Developing Alzheimer’s Disease

Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.

Featured Neurology Neuroscience

·June 25, 2021·4 min read

Subconscious Changes in Movement May Predict Alzheimer’s Disease

Subtle changes in fractal motor activity regulation in cognitively healthy women may be a sign of preclinical Alzheimer's disease, researchers report.

Featured Genetics Neurology Psychology

·June 17, 2021·3 min read

Depression and Tau Deposits Seen in Subset of Middle-Aged Persons

Depressed middle-aged carriers of the APOEe4 Alzheimer's genetic variant are at risk of developing tau accumulations in brain areas associated with emotion and memory.

This shows an older lady sitting on a swing, smiling at her husband

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·June 1, 2021·4 min read

Healthy Lifestyle Linked to Better Cognition for Oldest Adults, Regardless of Genetic Risk

Adults over 80 who maintained a healthy lifestyle, including exercise and diet, had a lower risk of cognitive decline, even if they had genetic risk factors for dementia.

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ApoE4

Genetic ‘Hotspots’ That Speed up and Slow Down Brain Aging Could Provide New Targets for Alzheimer’s Drugs

A Common Risk Factor for Alzheimer’s Disease May Predispose Carriers to Severe COVID-19

Neuroprotective Mechanism Altered by Alzheimer’s Disease Risk Genes

New Framework for Analyzing Alzheimer’s Disease Identifies Not One Form, but Three

Repurposing Cancer Drug to Treat Alzheimer’s in Those With Genetic Risk Factors

Key Alzheimer’s Feature Eliminated in Animal Model

Hit the Sleep Sweet Spot to Keep Brain Sharp

Water Pill May Be Viable to Test as Alzheimer’s Treatment

Stem Cells Model Genetic Risk for Developing Alzheimer’s Disease

Subconscious Changes in Movement May Predict Alzheimer’s Disease

Depression and Tau Deposits Seen in Subset of Middle-Aged Persons

Healthy Lifestyle Linked to Better Cognition for Oldest Adults, Regardless of Genetic Risk

Resetting Interneuron Timing Rescues Memory in Alzheimer’s

Boosting Wnt Signaling Reverses APOE4 Alzheimer’s Damage

How Stress Reactivates Arthritis

Reading Fiction Can Rewire Real-World Forgiveness and Empathy

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