Researchers report they have successfully erased damage caused by Apoe4 in Alzheimer's patients by altering the gene into a harmless Apoe3-like version.
Researchers report the closer a person gets to the age their parents started to develop Alzheimer's symptoms, the more likely they are to have amyloid plaques.
Even for those genetically susceptible to developing dementia, enhanced lifestyle counselling can help to prevent cognitive decline, a new study reports.
Researchers from WUSTL have identified a compound that targets APOE in mouse brains and which protects against Alzheimer's disease. The APOE4 genetic variant increases the risk of people developing Alzheimer's disease. The findings offer new possible avenues of treating the disease in humans.
Researchers report people with a genetic predisposition to Alzheimer's and who carry a variant in the RAB10 gene, may be more resilient to the disease than those without the genetic variant.
According to a new study, people who have inflammation biomarkers in their blood during middle age are more likely to have increased brain shrinkage as they grow older. Researchers report the brain cell loss associated with inflammation was most prevalent in areas affected in Alzheimer's disease.
Researchers are testing whether low doses of Rapamycin, a drug most commonly used as an immunosuppressant following an organ transplant, can help to prevent Alzheimer's disease.
UCSF researchers have developed a new genetic risk factor test that takes into account more than 24 genetic variants, each of which are associated with a small risk of Alzheimer's disease. The researchers say the test is a better method to help identify preclinical Alzheimer's than testing for ApoE4 alone.
Researchers are testing a new vaccine and oral medication that could delay or prevent Alzheimer's disease from developing in those with a genetic predisposition.
A new method of examining blood plasma allowed researchers to identify specific chemical bonds within the blood. The new technique allowed researchers to accurately distinguish between Alzheimer's disease and Lewy body dementia, thus reducing cases of misdiagnosis.
Researchers have implicated TOMM40, a gene adjacent to APOE on chromosome 19, in the development of Alzheimer's disease. TOMM40, researchers report, plays a significant role in the decline of verbal learning after the age of 60.