Researchers have identified how specific genetic mutations cause ALS. The pathway, they believe, may also be responsible for the development of frontotemporal dementia. Read More
In mouse models of Alzheimer's disease, active neurons still encode memory, and a group of active neurons encodes novel environmental information. The signal of the novelty containing neurons causes a superimposition disturbing the signal of memory encoding neurons. Read More
Repetitive negative thinking (RNT) in those aged over 55 is associated with an increased risk of cognitive decline and deposition of proteins associated with Alzheimer's disease. People who exhibited higher levels of RNT experienced more cognitive and memory problems over four years. They were more likely to have both amyloid-beta and tau protein deposits throughout the brain. Read More
Females who attend school for longer have better memory ability in old age, a new study reports. For each year of education, memory gains were, on average, five times greater for women than the losses experienced due to each year of aging. Read More
Changes in gut mucus may contribute to Alzheimer's, Parkinson's, and other neurological disorders. Researchers noted changes in types of gut mucus bacteria in those with a range of neurological disorders compared to their healthy peers. Findings suggest those with reduced gut mucus protection may be more susceptible to gastrointestinal problems. Read More
Tau spreads through the human brain via neural communication pathways. The spread is accelerated by the presence of amyloid-beta. Read More
People with the Alzheimer's associated ApoE e4e4 gene have increased vulnerability to developing severe symptoms of COVID-19 if they become infected with the virus. Findings suggest those with the dementia-related gene have double the risk of developing severe coronavirus symptoms compared to those who those with the common e3e3 form of the APOE gene. Read More
Researchers have identified a new, early biomarker for amyotrophic lateral sclerosis (ALS) on the teeth of children. Patients who were diagnosed with ALS in adulthood showed signs of dysregulation uptake of a mixture of essential elements, including zinc, copper, lead, and tin, on their teeth. The study is the first to show clear signatures at birth and within the first decade of life for ALS. Read More
Researchers have uncovered the process by which air pollution can damage brain cells, leading to an increased risk of Parkinson's disease. Chemicals found in diesel fuel reduced autophagic flux, which is a major pathway implicated in neurodegeneration. Read More
Human iPSCs transplanted into animal models of multiple sclerosis help repair cell damage and restore function. Read More
Subjective cognitive complaints may be the earliest detectable stages of preclinical dementia. Read More
Study reveals a new gut-brain connection in amyotrophic lateral sclerosis (ALS). The gut microbiome could influence the severity of the neurodegenerative disease. Altering the bacteria in the gut may prevent or improve symptoms of ALS. Read More
