neurodegenerative diseases

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neurodegenerative diseases

·October 5, 2021·4 min read

Study Detects Origins of Huntington’s Disease in Two-Week-Old Human Embryos

Synthesizing a human embryo from stem cells and using gene editing to insert the Huntingtin gene, researchers found the mutation affected the size of germ layers compared to the control embryos. Findings suggest Huntington's disease may be a neurodevelopmental disorder that presents as a neurodegenerative disease later

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·September 13, 2021·5 min read

Study Finds Evidence of Possible Link Between Herpes Simplex and Neurogenerative Diseases

Researchers discovered mutations of the OPTN gene resulted in increased herpesvirus 1 growth in the brains of mice, leading to the death of local neurons. This resulted in accelerated neurodegeneration. OPTN deficiency was also associated with impairments in immune response. While these findings are specific to the HSV-1 virus, researchers believe the findings may apply to up to eight herpesvirus infections.

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·September 8, 2021·2 min read

New Information on the Early Stages of Dementia With Lewy Bodies

New findings reinforce the idea that dementia with Lewy bodies can be pathologically classified as two different and distinct disease types.

Electrophysiology Featured Neuroscience Open Neuroscience Articles

·August 19, 2021·5 min read

Flawed Quality Control in the Brain

A new mouse line makes the state of protein balance visible in the mammalian brain for the first time, allowing researchers to investigate disorders associated with protein misfolding.

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·August 14, 2021·3 min read

A New Way to Study Neurodegenerative Diseases

Researchers have developed a new technique to quantify protein droplets associated with a range of neurodegenerative diseases, including Alzheimer's, Parkinson's, and ALS.

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·August 6, 2021·5 min read

Key Hallmark of ALS Reversed

Researchers reveal how proteins accumulate in the incorrect parts of brain cells in ALS, and demonstrate how it may be possible to reverse the accumulation.

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·July 19, 2021·3 min read

Chemists Found an Effective Remedy for “Aged” Brain Diseases

Newly synthesized compounds can halt the degradation of neurons in a range of neurodegenerative diseases, including Alzheimer's and Parkinson's disease, researchers say.

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·July 15, 2021·4 min read

Autophagy May Be the Key to Finding Treatments for Early Huntington’s Disease

Disruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.

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·June 27, 2021·3 min read

Differences in Human, Mouse Brain Cells Have Important Implications for Disease Research

A new study reveals humans and mice have significant differences in how oxidative stress and inflammation trigger immune response genes in astrocytes. Researchers suggest lab models of neurodegeneration should incorporate specially engineered mouse models with lower resistance to oxidative stress, rendering them more human-like.

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·June 7, 2021·6 min read

Simple Blood Test Can Accurately Reveal Underlying Neurodegeneration

NfL, a single biomarker in the blood, can accurately predict the presence of underlying neurodegenerative disorders, such as FTD and ALS, in people with cognitive problems.

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·May 6, 2021·5 min read

New Evidence Links Gut Bacteria and Neurodegenerative Conditions

A new study reports on an association between specific gut bacteria species and the manifestation of neurodegenerative disorders.

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·March 16, 2021·3 min read

How Sex Differences Play a Role in Neurological Diseases

Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.

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