Newly synthesized compounds can halt the degradation of neurons in a range of neurodegenerative diseases, including Alzheimer's and Parkinson's disease, researchers say.
Disruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.
A new study reveals humans and mice have significant differences in how oxidative stress and inflammation trigger immune response genes in astrocytes. Researchers suggest lab models of neurodegeneration should incorporate specially engineered mouse models with lower resistance to oxidative stress, rendering them more human-like.
NfL, a single biomarker in the blood, can accurately predict the presence of underlying neurodegenerative disorders, such as FTD and ALS, in people with cognitive problems.
Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.
Study sheds light on what causes normal proteins to convert to a diseased form associated with CJD and Kuru.
Non-invasive focused ultrasound appears to be beneficial in the treatment of Parkinson's disease for patients whose symptoms are poorly controlled by traditional medications.
In mouse models of Alzheimer's disease, active neurons still encode memory, and a group of active neurons encodes novel environmental information. The signal of the novelty containing neurons causes a superimposition disturbing the signal of memory encoding neurons.
Repetitive negative thinking (RNT) in those aged over 55 is associated with an increased risk of cognitive decline and deposition of proteins associated with Alzheimer's disease. People who exhibited higher levels of RNT experienced more cognitive and memory problems over four years. They were more likely to have both amyloid-beta and tau protein deposits throughout the brain.