Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.
Study sheds light on what causes normal proteins to convert to a diseased form associated with CJD and Kuru.
Non-invasive focused ultrasound appears to be beneficial in the treatment of Parkinson's disease for patients whose symptoms are poorly controlled by traditional medications.
Researchers find a previously unknown connection between ALS, FTD, and the Huntington's disease associated gene, huntingtin.
Researchers have identified how specific genetic mutations cause ALS. The pathway, they believe, may also be responsible for the development of frontotemporal dementia.
In mouse models of Alzheimer's disease, active neurons still encode memory, and a group of active neurons encodes novel environmental information. The signal of the novelty containing neurons causes a superimposition disturbing the signal of memory encoding neurons.
Repetitive negative thinking (RNT) in those aged over 55 is associated with an increased risk of cognitive decline and deposition of proteins associated with Alzheimer's disease. People who exhibited higher levels of RNT experienced more cognitive and memory problems over four years. They were more likely to have both amyloid-beta and tau protein deposits throughout the brain.
Females who attend school for longer have better memory ability in old age, a new study reports. For each year of education, memory gains were, on average, five times greater for women than the losses experienced due to each year of aging.
Changes in gut mucus may contribute to Alzheimer's, Parkinson's, and other neurological disorders. Researchers noted changes in types of gut mucus bacteria in those with a range of neurological disorders compared to their healthy peers. Findings suggest those with reduced gut mucus protection may be more susceptible to gastrointestinal problems.
Tau spreads through the human brain via neural communication pathways. The spread is accelerated by the presence of amyloid-beta.
People with the Alzheimer's associated ApoE e4e4 gene have increased vulnerability to developing severe symptoms of COVID-19 if they become infected with the virus. Findings suggest those with the dementia-related gene have double the risk of developing severe coronavirus symptoms compared to those who those with the common e3e3 form of the APOE gene.
Researchers have identified a new, early biomarker for amyotrophic lateral sclerosis (ALS) on the teeth of children. Patients who were diagnosed with ALS in adulthood showed signs of dysregulation uptake of a mixture of essential elements, including zinc, copper, lead, and tin, on their teeth. The study is the first to show clear signatures at birth and within the first decade of life for ALS.
