New insights into what may go awry in brains of Alzheimer’s patients
Amyloid beta may be less harmful than previously thought. However, an age-damaged version of the protein may be more harmful.... Read More...
amyloid-beta
Blood test 94% accurate at identifying Alzheimer’s before symptoms appear
A new blood test for Alzheimer's disease is up-to 94% accurate at predicting dementia before symptoms appear. The test's accuracy is increased when genetic predisposition and age are taken into account. The new test may eventually replace PET neuroimaging, currently considered the gold standard, for early detection of Alzheimer's. ... Read More...
Novel discovery of links between liver dysfunction and Alzheimer’s disease
A link between liver dysfunction and Alzheimer's disease has been discovered. The findings add to the understanding of the role metabolic dysfunction plays in the neurodegenerative disease.... Read More...
Risk and progression of Alzheimer’s disease differ by gender
The risk of developing Alzheimer's disease is increased, and progression more rapid in women due to larger brain-wide accumulation and acceleration in the spread of tau. ... Read More...
Sorting protein in neurons defends against neurodegenerative disease
VPS35 is a novel critical component of tau metabolism and the pathology of neurodegenerative diseases. ... Read More...
New blood test for detecting Alzheimer’s disease to undergo trial
A new blood test to detect biomarkers for Alzheimer's disease is set to undergo trials in the Fall. The test will be able to identify traces of amyloid beta in blood samples with a high degree of accuracy.... Read More...
Study connects low social engagement to amyloid levels and cognitive decline
An association has been discovered between cognitive decline and social engagement in older adults. Older people who are less socially active have a greater accumulation of amyloid beta and increased cognitive decline over a three-year span, compared to more socially active peers.... Read More...
Disrupted sleep in one’s 50s, 60s raises risk of Alzheimer’s disease
Sleep disruptions during middle age may be a potential biomarker for developing Alzheimer's disease later in life. Researchers found those who experienced sleep problems in their 40s and 50s had more amyloid beta accumulation in their brains later in life. Those whose sleep problems started in their 50s and 60s had increased levels of tau. Additionally, higher levels of tau were discovered in the brains of those who lacked synchronized brain waves associated with a good night's sleep.... Read More...
Alzheimer’s missing link ID’d, answering what tips brain’s decline
Study in mice and humans reveals reinforcing the activity of microglia could slow, or potentially halt, the proliferation of Tau tangles in Alzheimer's disease.... Read More...
Squeezing of blood vessels may contribute to cognitive decline in Alzheimer’s
Capillary constriction caused by amyloid beta restricts cerebral blood flow in mouse models of Alzheimer's disease. Inhibiting the capillary constriction may potentially reduce some of the neurodegenerative features of Alzheimer's.... Read More...
Sleep history predicts late-life Alzheimer’s pathology
Your sleep history during middle age may predict Alzheimer's pathology later in life. A decrease in sleep quality between 50 and 70 years of age is associated with higher levels of tau and amyloid beta in the brain. Changes in brain activity and quality of sleep could be a biomarker for Alzheimer's disease.... Read More...
Modified protein can prevent Alzheimer’s disease in mice
Researchers injected a modified segment of the amyloid precursor protein into mouse models of Alzheimer's disease. The treatment appeared to reverse a number of the cognitive and memory problems associated with the neurodegenerative disease.... Read More...