Increased accumulation of amyloid beta and a reduction of serotonin in the brains of older adults was associated with higher risks for developing depression later in life.
Newly designed antibodies that bind to small clumps of amyloid-beta may keep the progression of Alzheimer's disease in check.
Drugs that stabilize amyloid fibril "frustration" block further aggregation and could provide a new method to prevent the progression of Alzheimer's.
Hyperbaric oxygen therapy improved cerebral blood flow by up to 23%, alleviating vascular dysfunction and amyloid burden in elderly patients. The treatment also improved memory by 16.5%.
A newly developed brain model from cultivated stem cells allowed researchers to analyze molecular pathways of neurons in a dish. Researchers identified specific forms of amyloid beta and tau associated with cognitive decline and Alzheimer's. They also uncovered signaling pathways that influence the production of the toxic proteins.
The presence of amyloid-beta deposits in the retina correlated with cerebral amyloid levels in those with Alzheimer's disease. The findings may lead to methods for the earlier detection of Alzheimer's.
Amyloid-beta accumulates in nerve cells and spreads, from cell to cell, via nerve fibers. This process occurs prior to the formation of amyloid plaques in the brain.
A new advanced imaging technique shows how cholesterol regulates the production of Alzheimer's associated amyloid beta proteins in astrocytes.
Dipeptidyl peptidase-4 inhibitors, a class of drug that reduces blood sugar in type 2 diabetes, were associated with less amyloid accumulation in the brain and slower cognitive decline in patients.
Researchers have developed a new brain organoid model to study the mechanistic causes of Alzheimer's disease and test dementia drugs currently in development.
Lower blood levels of amyloid-beta 42 during mid-life were associated with a higher risk of dementia and a marginally increased risk of mild cognitive impairment later in life, a new study reports.
Study establishes a comprehensive single-nucleus transcriptomic atlas of the aging primate hippocampus and provides key information about age-related molecular signatures at the single-cell level.
