amyloid-beta

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amyloid-beta

·June 23, 2020

New gene may drive earliest brain changes in Alzheimer’s

Genetic analysis of almost 4,300 samples reveals a link between the appearance of amyloid deposits, APOE, and a novel gene called RBFOX1. Lower levels of RBFOX1 in the brain appear to be associated with increased amyloid and global cognitive decline over a person's lifetime. Read More

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·May 29, 2020

How toxic protein spreads in Alzheimer’s disease

Tau spreads through the human brain via neural communication pathways. The spread is accelerated by the presence of amyloid-beta. Read More

Featured Neurology Neuroscience

·May 11, 2020

3D brain-like tissue model links Alzheimer’s disease with herpes

A 3D human tissue culture model demonstrated a possible causal relationship between Alzheimer's disease and herpes simplex virus 1 (HSV-1) infection. 40 Alzheimer's associated genes were over-expressed in the HSV-1 infected brain tissue, including genes associated with the production of amyloid-beta. Read More

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·April 30, 2020

Nanodevices for the brain could thwart formation of Alzheimer’s plaques

Researchers have developed a new approach to prevent amyloid plaque formation by engineering a nanodevice that captures the peptides before they can assemble. The silica nanodevice might be a new tool in the treatment and prevention of Alzheimer's disease and other neurodegenerative diseases associated with amyloid-beta. Read More

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·March 18, 2020

Alzheimer’s risk genes converge on microglia

Findings indicate a large part of the genetic risk of Alzheimer's involves a microglial response to amyloid-beta. Read More

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·February 17, 2020

Beta-arrestin-2 increases neurotoxic tau driving frontotemporal dementia

The protein beta-arrestin-2 increases tau tangle accumulation in Alzheimer's disease and frontotemporal dementia but interfering with the removal of excess tau from the brain. Read More

Featured Genetics Neurology Neuroscience

·February 14, 2020

Subtle decline in cognition predicts progression to Alzheimer’s pathology

Cognitive performance may predict the progression from normal to abnormal levels of Alzheimer's associated amyloid-beta. Read More

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·January 28, 2020

New mathematical model for amyloid formation

Mathematical model describes the chemical reactions responsible for the formation of Alzheimer's-linked protein. Read More

This shows an old man sitting on a park bench

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·January 25, 2020

Lithium may halt Alzheimer’s progression

More commonly associated with treating bipolar disorder, microdoses of lithium may halt the progression of Alzheimer's disease. Read More

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·January 21, 2020

Possible Alzheimer’s breakthrough suggested

A previously unknown gene and associated protein have been linked to the development of Alzheimer's disease. By suppressing the protein, named Aggergatin by the researchers, it may be possible to slow down or prevent the development of the neurodegenerative disease. Read More

This shows amyloid beta and aluminum traces in the brain sample

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·January 20, 2020

Human Exposure to Aluminum Linked to Familial Alzheimer’s Disease

Researchers found a close association between high aluminum content in brain tissue and amyloid-beta location in post-mortem samples of people with familial Alzheimer's disease. The findings back up previous claims that aluminum exposure may be linked to the development of the neurodegenerative disease. Read More

Featured Neurology Neuroscience

·January 1, 2020

Objective subtle cognitive difficulties predict amyloid accumulation and neurodegeneration

Amyloid accumulation occurs faster in those who have objectively-defined cognitive difficulties than older people who are considered to be cognitively normal. Mild cognitive impairment is also associated with faster hippocampal and entorhinal cortex atrophy. Read More

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