amyloid-beta

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amyloid-beta

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·June 5, 2022·5 min read

Alzheimer’s Disease Causes Cells to Overheat and ‘Fry Like Eggs’

The heat produced by amyloid-beta aggregation may cause other, healthy amyloid-beta to aggregate, causing more and more aggregates to form. However, with the addition of a novel drug compound, amyloid-beta aggregation can be stopped and the cell temperature lowered.

Featured Neurology Neuroscience

·June 2, 2022·5 min read

Evidence Mounts for Alternate Origins of Alzheimer’s Disease Plaques

A new mouse study reveals a breakdown in the process that clears brain cells of waste products precedes the buildup of amyloid plaques associated with Alzheimer's disease.

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Featured Neurology Neuroscience

·May 14, 2022·6 min read

Combination of ‘Feelings’ and Measurements Suggest Alzheimer’s in the Early Stage

A combination of patient-reported subjective cognitive impairment and measurable clinical symptoms, such as amyloid-beta accumulation in the cerebrospinal fluid, may help in the early diagnosis of Alzheimer's disease.

Featured Neurology Neuroscience

·May 6, 2022·6 min read

Study Preserves Memory in Mice, Offering Promising New Basis for Active Immunization Against Alzheimer’s Disease

The corn-derived MetO-rich protein, when injected, prompts the immune system to produce antibodies against the MetO component of amyloid beta. Older mice injected with the MetO-rich protein showed 50% improvement in memory compared to the control animals. The findings could be key to the development of a potential vaccine for Alzheimer's.

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Featured Neurology Neuroscience

·May 2, 2022·5 min read

Brain Connectivity Changes Revealed in Individuals With Pre-clinical Alzheimer’s Disease

The accumulation of amyloid-beta and tau proteins disrupts the connections between brain regions associated with memory years before symptoms of Alzheimer's disease appear.

Featured Neurology Neuroscience

·May 1, 2022·4 min read

New Blood Biomarker for Predicting Dementia Before Symptoms Develop

Measuring blood levels of P-tau181 may allow doctors to diagnose Alzheimer's before the onset of symptoms. Elevated levels of P-tau181 in the blood were associated with greater amyloid beta accumulation in the brain and outperformed two other biomarkers in predicting signs of amyloid beta in brain scans.

Featured Genetics Neurology Neuroscience

·April 20, 2022·5 min read

Single-Cell DNA Sequencing Offers a New Angle on the Causes of Alzheimer’s Disease

An abundance of newly acquired mutations in the mutations that occur at an accelerated speed is a telling pattern of Alzheimer's disease, researchers report.

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·April 19, 2022·4 min read

Psychiatric Symptoms in Alzheimer’s Disease

Like cognitive deficits, psychiatric symptoms such as depression, apathy, and anxiety associated with Alzheimer's disease appear to be a direct consequence of underlying brain changes as a result of increased amyloid-beta accumulation.

Featured Neurology Neuroscience

·March 2, 2022·2 min read

Drug Candidate Reduced Brain Inflammation and Protected Against Cognitive Decline in Alzheimer’s Mouse Model

3,6’-dithiopomalidomide (DP), an anti-inflammatory drug candidate, protected mouse models of Alzheimer's disease against cognitive decline by reducing neuroinflammation.

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Featured Neurology Neuroscience

·February 24, 2022·3 min read

Having a Poor Score on a Simple Memory Test May Be Linked to Alzheimer’s Biomarkers

Even for older people experiencing no general memory or thinking problems, performing poorly on a simple memory test may be linked to biomarkers for Alzheimer's disease.