Bexarotene, an anti-cancer drug which is about to be tested in a clinical trial as a potential treatment for Alzheimer's disease, fails to reduce amyloid plagues; according to researchers replicating the original study.
Researchers have found compelling evidence that older adults can eliminate forgetfulness and perform as well as younger adults on memory tests. The findings have intriguing implications for designing learning strategies for older adults.
Researchers combined genetic data with neuroimaging in order to identify genes associated with amyloid plaque deposits in Alzheimer's disease patients. The study is believed to be the first genome-wide association study of plaque deposits using a specialized PET scan tracer that binds to amyloid.
Researchers upend a long-held view about the basic functioning of a key receptor molecule involved in signaling between neurons. The study describes how a compound linked to Alzheimer's disease impacts NMDA receptors and weakens synaptic connections between brain cells.
Researchers recently developed a system for observing real-time brain activity in a live mouse. The device could prove useful in studying new treatments for Alzheimer's and other neurodegenerative diseases.
Researchers discover neuronal activity can stimulate tau release from healthy neurons in the absence of cell death. The study shows treatment of neurons with known biological signaling molecules increases the release of tau into the culture medium.
Researchers discovered that a low protein diet can slow the progression of Alzheimer's disease in mice. By cycling between a normal and protein restricted diet, researchers noted both improvement in memory and a slowing in the advancement of the disease.
While evidence suggests pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals, new research shows no evidence to support concerns that these abnormal disease proteins are “infectious” or transmitted from animals to humans or from one person to another.